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10.1080/15592294.2017.1290032 http://scihub22266oqcxt.onion/10.1080/15592294.2017.1290032 C5453194!5453194!28277979     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Epigenetics 2017 ; 12 (5): 340-52 Nephropedia Template TP {{tp|p=28277979|t=2017. Structural insight into inhibitors of flavin adenine dinucleotide-dependent lysine demethylases |pdf=|usr=}}{{28277979}} gab.com Text Structural insight into inhibitors of flavin adenine dinucleotide-dependent lysine demethylases JO: Epigenetics http://www.kidney.de/pget.php?&tw=1&pmid=28277979 #FOAvip Until 2004, many researchers believed that protein methylation in eukaryotic cells was an irreversible reaction. However, the discovery of lysine-specific demethylase 1 in 2004 drastically changed this view and the concept of chromatin regulation. Since then, the enzymes responsible for lysine demethylation and their cellular substrates, biological significance, and selective regulation have become major research topics in epigenetics and chromatin biology. Many cell-permeable inhibitors for lysine demethylases have been developed, including both target-specific and nonspecific inhibitors. Structural understanding of how these inhibitors bind to lysine demethylases is crucial both for validation of the inhibitors as chemical probes and for the rational design of more potent, target-specific inhibitors. This review focuses on published small-molecule inhibitors targeted at the two flavin adenine dinucleotide-dependent lysine demethylases, lysine-specific demethylases 1 and 2, and how the inhibitors interact with the tertiary structures of the enzymes. Twit Text FOAVip Structural insight into inhibitors of flavin adenine dinucleotide-dependent lysine demethylases ????Epigenetics http://www.kidney.de/pget.php?&tw=1&pmid=28277979 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28277979 #FOAvip English Wikipedia <ref>{{Cite pmid|28277979}}</ref> Structural insight into inhibitors of flavin adenine dinucleotide-dependent lysine demethylases #MMPMID28277979 Niwa H; Umehara T Epigenetics 2017[]; 12 (5): 340-52 PMID28277979show ga Until 2004, many researchers believed that protein methylation in eukaryotic cells was an irreversible reaction. However, the discovery of lysine-specific demethylase 1 in 2004 drastically changed this view and the concept of chromatin regulation. Since then, the enzymes responsible for lysine demethylation and their cellular substrates, biological significance, and selective regulation have become major research topics in epigenetics and chromatin biology. Many cell-permeable inhibitors for lysine demethylases have been developed, including both target-specific and nonspecific inhibitors. Structural understanding of how these inhibitors bind to lysine demethylases is crucial both for validation of the inhibitors as chemical probes and for the rational design of more potent, target-specific inhibitors. This review focuses on published small-molecule inhibitors targeted at the two flavin adenine dinucleotide-dependent lysine demethylases, lysine-specific demethylases 1 and 2, and how the inhibitors interact with the tertiary structures of the enzymes. äStructural insight into inhibitors of flavin adenine dinucleotide-depe(epmc).pdf DeepDyve Pubget Overpricing