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2017 ; 13
(6
): 4475-4480
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Recombinant fibromodulin and decorin effects on NF-?B and TGF?1 in the 4T1 breast
cancer cell line
#MMPMID28599447
Dawoody Nejad L
; Biglari A
; Annese T
; Ribatti D
Oncol Lett
2017[Jun]; 13
(6
): 4475-4480
PMID28599447
show ga
Constitutive activation of nuclear factor-?B (NF-?B) stimulates cell
proliferation and metastasis, and inhibits apoptosis in breast cancer.
Transforming growth factor-? (TGF-?) signaling pathway is deregulated in breast
cancer progression and metastasis. The aim of the present study was to
investigate the inhibitory effects of the two small leucine rich proteoglycans
fibromodulin (Fmod) and decorin (Dcn), overexpressed using adenovirus gene
transfer, on NF-?B-activity and TGF-?1-expression in the highly metastatic 4T1
breast cancer cell line. The results demonstrate that Fmod and Dcn overexpression
is associated with NF-?B and TGF-?1 downregulation, and that Fmod promotes this
effect more effectively compared with Dcn.