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10.3892/ol.2017.6081 http://scihub22266oqcxt.onion/10.3892/ol.2017.6081 C5452933!5452933 !28588728     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28588728 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28588728 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncol+Lett 2017 ; 13 (6 ): 4794-4798 Nephropedia Template TP {{tp|p=28588728 |t=2017. Maternal embryonic leucine zipper kinase inhibits epithelial-mesenchymal transition by regulating transforming growth factor-? signaling |pdf=|usr=}}{{28588728 }} gab.com Text Maternal embryonic leucine zipper kinase inhibits epithelial-mesenchymal transition by regulating transforming growth factor- signaling JO: Oncol Lett http://www.kidney.de/pget.php?&tw=1&pmid=28588728 #FOAvip Maternal embryonic leucine zipper kinase (MELK) performs an important role in self-renewal and proliferation of progenitor cells or tumor stem cells, and is expressed in aggressive cancers, contributing to tumorigenesis. However, the function of MELK in metastasis is unknown. In the present study, the lung cancer A549 cell line was utilized in order to study the role of MELK in epithelial-mesenchymal transitions (EMTs), the initial step of tumor metastasis. It was identified that transforming growth factor-? (TGF-?) could downregulate the expression of MELK, and that MELK could inhibit EMT by regulating TGF-? signaling. MELK can interact with Smad proteins, which represses TGF-?/Smad-mediated signaling activity. The findings of the present study identified the effect of MELK in TGF-? signaling and the EMT process. Twit Text FOAVip Maternal embryonic leucine zipper kinase inhibits epithelial-mesenchymal transition by regulating transforming growth factor- signaling ????Oncol Lett http://www.kidney.de/pget.php?&tw=1&pmid=28588728 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28588728 #FOAvip English Wikipedia <ref>{{Cite pmid|28588728 }}</ref> Maternal embryonic leucine zipper kinase inhibits epithelial-mesenchymal transition by regulating transforming growth factor-? signaling #MMPMID28588728 Cheng J ; Qin B ; Liu B ; Huang T ; Li Y ; Ma L Oncol Lett 2017[Jun]; 13 (6 ): 4794-4798 PMID28588728 show ga Maternal embryonic leucine zipper kinase (MELK) performs an important role in self-renewal and proliferation of progenitor cells or tumor stem cells, and is expressed in aggressive cancers, contributing to tumorigenesis. However, the function of MELK in metastasis is unknown. In the present study, the lung cancer A549 cell line was utilized in order to study the role of MELK in epithelial-mesenchymal transitions (EMTs), the initial step of tumor metastasis. It was identified that transforming growth factor-? (TGF-?) could downregulate the expression of MELK, and that MELK could inhibit EMT by regulating TGF-? signaling. MELK can interact with Smad proteins, which represses TGF-?/Smad-mediated signaling activity. The findings of the present study identified the effect of MELK in TGF-? signaling and the EMT process. äMaternal embryonic leucine zipper kinase inhibits epithelial-mesenchym(epmc).pdf DeepDyve Pubget Overpricing