Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28569187
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 BMC+Nephrol
2017 ; 18
(1
): 182
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
The effects of acute renal denervation on kidney perfusion and metabolism in
experimental septic shock
#MMPMID28569187
Post EH
; Su F
; Hosokawa K
; Taccone FS
; Herpain A
; Creteur J
; De Backer D
; Vincent JL
BMC Nephrol
2017[May]; 18
(1
): 182
PMID28569187
show ga
BACKGROUND: Perfusion deficits likely play an important role in the development
of renal dysfunction in sepsis. Renal denervation may improve kidney perfusion
and metabolism. METHODS: We randomized 14 female sheep to undergo bilateral
surgical renal denervation (n = 7) or sham procedure (n = 7) prior to induction
of sepsis. Renal blood flow (RBF) was measured with a pre-calibrated flowprobe.
Laser Doppler probes were implanted to measure cortical and medullary perfusion.
Cortical glucose, lactate and pyruvate levels were measured using the
microdialysis technique. Creatinine clearance was determined. Sepsis was induced
by peritonitis and fluid resuscitation was provided to avoid hypovolemia.
RESULTS: RBF and cortical perfusion were higher in the denervated group during
the first 6 h after induction of sepsis (P < 0.001 and P < 0.05, respectively),
while medullary perfusion decreased similarly in both groups. After hypotension
developed, RBF decreased to similar levels in both groups. Cortical pyruvate and
lactate levels were lower in the denervated animals (P < 0.001 and P < 0.001,
respectively). There were no differences between groups in creatinine clearance,
urine output or time to oliguria. CONCLUSION: Denervation thus caused an early
increase in RBF that was distributed towards the kidney cortex. Although
associated with an attenuation of early cortical metabolic alterations,
denervation failed to prevent the deterioration in renal function.
free
free
free
