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10.1242/dmm.028613

http://scihub22266oqcxt.onion/10.1242/dmm.028613
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C5451173!5451173!28468937
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suck abstract from ncbi

pmid28468937      Dis+Model+Mech 2017 ; 10 (5): 509-18
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  • RNA metabolism in neurodegenerative disease #MMPMID28468937
  • Liu EY; Cali CP; Lee EB
  • Dis Model Mech 2017[May]; 10 (5): 509-18 PMID28468937show ga
  • Aging-related neurodegenerative diseases are progressive and fatal neurological diseases that are characterized by irreversible neuron loss and gliosis. With a growing population of aging individuals, there is a pressing need to better understand the basic biology underlying these diseases. Although diverse disease mechanisms have been implicated in neurodegeneration, a common theme of altered RNA processing has emerged as a unifying contributing factor to neurodegenerative disease. RNA processing includes a series of distinct processes, including RNA splicing, transport and stability, as well as the biogenesis of non-coding RNAs. Here, we highlight how some of these mechanisms are altered in neurodegenerative disease, including the mislocalization of RNA-binding proteins and their sequestration induced by microsatellite repeats, microRNA biogenesis alterations and defective tRNA biogenesis, as well as changes to long-intergenic non-coding RNAs. We also highlight potential therapeutic interventions for each of these mechanisms.
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