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10.3390/antib4040354 http://scihub22266oqcxt.onion/10.3390/antib4040354 C5451160!5451160 !28580178     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28580178 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Antibodies+(Basel) 2015 ; 4 (ä): 354-368 Nephropedia Template TP {{tp|p=28580178 |t=2015. Antibody Reactivity of B Cells in Lupus Patients with Increased Disease Activity and ARID3a Expression |pdf=|usr=}}{{28580178 }} gab.com Text Antibody Reactivity of B Cells in Lupus Patients with Increased Disease Activity and ARID3a Expression JO: Antibodies (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=28580178 #FOAvip Earlier studies showed that the DNA-binding protein, Bright/ARID3a bound to a subset of human and mouse immunoglobulin heavy chain promoters where it enhanced expression. Indeed, mice with transgenic expression of ARID3a in all B lymphocytes have expanded MZ B cells and produce anti-nuclear antibodies (ANAs). Consistent with our findings in mice, we observed that human systemic lupus erythematosus (SLE) patients had expanded numbers of peripheral blood ARID3a(+) B cells that were associated with increased disease activity (p = 0.0038). We hypothesized that ARID3a(+) naïve B cells would eventually produce autoantibodies, explaining associations between ARID3a expression and disease activity in lupus. Unlike healthy controls, ARID3a was expressed in the naïve B cell population in SLE patients, and we hypothesized that these might represent expansions of autoreactive cells. Therefore, monoclonal antibodies were generated from single-sorted naïve B cells derived from patients with normal (ARID3a(N)) and high (ARID3a(H)) numbers of ARID3a(+) B cells. We found that ARID3a expression did not correlate with autoantibody expression. Furthermore, measures of antigen specificities of autoreactive antibodies did not reveal skewing toward particular proteins. These data suggest that the association of increased disease activity in SLE with numbers of ARID3a(+) B lymphocytes may be mediated by an antibody-independent mechanism. Twit Text FOAVip Antibody Reactivity of B Cells in Lupus Patients with Increased Disease Activity and ARID3a Expression ????Antibodies (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=28580178 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28580178 #FOAvip English Wikipedia <ref>{{Cite pmid|28580178 }}</ref> Antibody Reactivity of B Cells in Lupus Patients with Increased Disease Activity and ARID3a Expression #MMPMID28580178 Ward JM ; James JA ; Zhao YD ; Webb CF Antibodies (Basel) 2015[Dec]; 4 (ä): 354-368 PMID28580178 show ga Earlier studies showed that the DNA-binding protein, Bright/ARID3a bound to a subset of human and mouse immunoglobulin heavy chain promoters where it enhanced expression. Indeed, mice with transgenic expression of ARID3a in all B lymphocytes have expanded MZ B cells and produce anti-nuclear antibodies (ANAs). Consistent with our findings in mice, we observed that human systemic lupus erythematosus (SLE) patients had expanded numbers of peripheral blood ARID3a(+) B cells that were associated with increased disease activity (p = 0.0038). We hypothesized that ARID3a(+) naïve B cells would eventually produce autoantibodies, explaining associations between ARID3a expression and disease activity in lupus. Unlike healthy controls, ARID3a was expressed in the naïve B cell population in SLE patients, and we hypothesized that these might represent expansions of autoreactive cells. Therefore, monoclonal antibodies were generated from single-sorted naïve B cells derived from patients with normal (ARID3a(N)) and high (ARID3a(H)) numbers of ARID3a(+) B cells. We found that ARID3a expression did not correlate with autoantibody expression. Furthermore, measures of antigen specificities of autoreactive antibodies did not reveal skewing toward particular proteins. These data suggest that the association of increased disease activity in SLE with numbers of ARID3a(+) B lymphocytes may be mediated by an antibody-independent mechanism. äAntibody Reactivity of B Cells in Lupus Patients with Increased Diseas(epmc).pdf DeepDyve Pubget Overpricing