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10.3389/fnmol.2017.00174 http://scihub22266oqcxt.onion/10.3389/fnmol.2017.00174 C5450696!5450696!28620280     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Mol+Neurosci 2017 ; 10 (ä): ä Nephropedia Template TP {{tp|p=28620280|t=2017. Pathophysiology of Chemotherapy-Induced Peripheral Neuropathy |pdf=|usr=}}{{28620280}} gab.com Text Pathophysiology of Chemotherapy-Induced Peripheral Neuropathy JO: Front Mol Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=28620280 #FOAvip Chemotherapy-induced neuropathy is a common, dose-dependent adverse effect of several antineoplastics. It can lead to detrimental dose reductions and discontinuation of treatment, and severely affects the quality of life of cancer survivors. Clinically, chemotherapy-induced peripheral neuropathy presents as deficits in sensory, motor, and autonomic function which develop in a glove and stocking distribution due to preferential effects on longer axons. The pathophysiological processes are multi-factorial and involve oxidative stress, apoptotic mechanisms, altered calcium homeostasis, axon degeneration and membrane remodeling as well as immune processes and neuroinflammation. This review focusses on the commonly used antineoplastic substances oxaliplatin, cisplatin, vincristine, docetaxel, and paclitaxel which interfere with the cancer cell cycle?leading to cell death and tumor degradation?and cause severe acute and chronic peripheral neuropathies. We discuss drug mechanism of action and pharmacokinetic disposition relevant to the development of peripheral neuropathy, the epidemiology and clinical presentation of chemotherapy-induced neuropathy, emerging insight into genetic susceptibilities as well as current understanding of the pathophysiology and treatment approaches. Twit Text FOAVip Pathophysiology of Chemotherapy-Induced Peripheral Neuropathy ????Front Mol Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=28620280 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28620280 #FOAvip English Wikipedia <ref>{{Cite pmid|28620280}}</ref> Pathophysiology of Chemotherapy-Induced Peripheral Neuropathy #MMPMID28620280 Starobova H; Vetter I Front Mol Neurosci 2017[]; 10 (ä): ä PMID28620280show ga Chemotherapy-induced neuropathy is a common, dose-dependent adverse effect of several antineoplastics. It can lead to detrimental dose reductions and discontinuation of treatment, and severely affects the quality of life of cancer survivors. Clinically, chemotherapy-induced peripheral neuropathy presents as deficits in sensory, motor, and autonomic function which develop in a glove and stocking distribution due to preferential effects on longer axons. The pathophysiological processes are multi-factorial and involve oxidative stress, apoptotic mechanisms, altered calcium homeostasis, axon degeneration and membrane remodeling as well as immune processes and neuroinflammation. This review focusses on the commonly used antineoplastic substances oxaliplatin, cisplatin, vincristine, docetaxel, and paclitaxel which interfere with the cancer cell cycle?leading to cell death and tumor degradation?and cause severe acute and chronic peripheral neuropathies. We discuss drug mechanism of action and pharmacokinetic disposition relevant to the development of peripheral neuropathy, the epidemiology and clinical presentation of chemotherapy-induced neuropathy, emerging insight into genetic susceptibilities as well as current understanding of the pathophysiology and treatment approaches. äPathophysiology of Chemotherapy-Induced Peripheral Neuropathy (epmc).pdf DeepDyve Pubget Overpricing