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2017 ; 13
(6
): 3503-3508
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StatSensor-i point-of-care creatinine analyzer may identify patients at high-risk
of contrast-induced nephropathy
#MMPMID28587433
Inoue A
; Nitta N
; Ohta S
; Imoto K
; Yamasaki M
; Ikeda M
; Murata K
Exp Ther Med
2017[Jun]; 13
(6
): 3503-3508
PMID28587433
show ga
The current study assessed the accuracy of the StatSensor-i (STA) point-of-care
creatinine analyzer prior to and following adjustment (offset correction) by
linear regression scatter plots produced by the reference samples from patients
and volunteers for detecting high risk of contrast-induced nephropathy in
patients with an estimated glomerular filtration rate <45 ml/min/1.73 m(2). Blood
samples were obtained from 233 consecutive outpatients scheduled for
contrast-enhanced CT studies. Of the 233 patients, 123 patient samples were
evaluated prior to adjustment and the other 110 following adjustment. Serum
creatinine levels and estimated glomerular filtration rate were measured using
the analyzer and compared with the values returned by laboratory tests. Analysis
was with the paired t-test, the Pearson correlation coefficient and Bland-Altman
plotting. The sensitivity, specificity, positive and negative predictive values
(PPV, NPV), and accuracy for detecting patients with an estimated glomerular
filtration rate <45 ml/min/1.73 m(2) were subsequently calculated. Mean serum
creatinine levels measured with the analyzer were significantly higher than those
returned by laboratory tests before (P<0.0001) and after adjustment (P<0.01).
Following adjustment, the difference in serum creatinine values obtained with the
STA analyzer and by laboratory methods did not exceed 0.3 mg/dl. Prior to
adjustment, 9.7% of the samples were overdiagnosed as having an estimated
glomerular filtration rate of <45 ml/min/1.73 m(2); following adjustment, the
overdiagnosis rate was 2.7%. The sensitivity, specificity, PPV, NPV and accuracy
were 100, 89, 50, 100 and 90.2% before and 100, 96.3, 33.3, 100 and 96.4% after
adjustment, respectively. With the adjusted point-of-care creatinine analyzer,
estimated glomerular filtration rate may be reliably evaluated in the radiology
suite.