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10.1186/s12882-017-0590-x http://scihub22266oqcxt.onion/10.1186/s12882-017-0590-x C5450386!5450386!28558717     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28558717&cmd=llinks): Failed to open stream: HTTP request failed! 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Timing of commencement of maintenance dialysis and mortality in young and older adults in Singapore |pdf=|usr=}}{{28558717}} gab.com Text Timing of commencement of maintenance dialysis and mortality in young and older adults in Singapore JO: BMC Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=28558717 #FOAvip Background: The benefit of early dialysis initiation remains controversial with a paucity of data in Asians. Therefore, we undertook this study to investigate the association between timing of initiation of dialysis and mortality in Singapore. Methods: The study used data from the Singapore Renal Registry database on 3286 patients with incident end-stage renal disease (ESRD) who commenced maintenance dialysis between January 2008 and December 2011. The data was further linked with the National Death Registry to acquire survival information until December 2013. We classified serum creatinine-based, estimated glomerular filtration rate (eGFR) by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation at the start of dialysis into 3 categories: Early (?10 ml/min/1.73m2), intermediate (5 to <10 ml/min/1.73m2) and late (<5 ml/min/1.73m2). Results: In the unadjusted analysis, both early and intermediate dialysis initiation groups were at greater risk of death relative to late dialysis (Early: HR = 2.47; Intermediate: HR = 1.54). In the multivariate model, a significant interaction was detected between age and eGFR at dialysis initiation (p = 0.04). Adjusted mortality risk progressively increased with earlier initiation of dialysis for patients aged 18?54 years (p = 0.006) and aged 55 to 64 years (p < 0.001), and no statistically significant difference was observed for patients aged 65 years or older (p = 0.12). Conclusions: Early versus later initiation of dialysis was associated with significantly higher risk of mortality in Singapore?s non-elderly population, and appeared to offer no survival advantage among the elderly. Electronic supplementary material: The online version of this article (doi:10.1186/s12882-017-0590-x) contains supplementary material, which is available to authorized users. Twit Text FOAVip Timing of commencement of maintenance dialysis and mortality in young and older adults in Singapore ????BMC Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=28558717 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28558717 #FOAvip English Wikipedia <ref>{{Cite pmid|28558717}}</ref> Timing of commencement of maintenance dialysis and mortality in young and older adults in Singapore #MMPMID28558717 Feng L; Jin AZ; Allen JC; Chow KY; Jafar TH BMC Nephrol 2017[]; 18 (ä): ä PMID28558717show ga Background: The benefit of early dialysis initiation remains controversial with a paucity of data in Asians. Therefore, we undertook this study to investigate the association between timing of initiation of dialysis and mortality in Singapore. Methods: The study used data from the Singapore Renal Registry database on 3286 patients with incident end-stage renal disease (ESRD) who commenced maintenance dialysis between January 2008 and December 2011. The data was further linked with the National Death Registry to acquire survival information until December 2013. We classified serum creatinine-based, estimated glomerular filtration rate (eGFR) by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation at the start of dialysis into 3 categories: Early (?10 ml/min/1.73m2), intermediate (5 to <10 ml/min/1.73m2) and late (<5 ml/min/1.73m2). Results: In the unadjusted analysis, both early and intermediate dialysis initiation groups were at greater risk of death relative to late dialysis (Early: HR = 2.47; Intermediate: HR = 1.54). In the multivariate model, a significant interaction was detected between age and eGFR at dialysis initiation (p = 0.04). Adjusted mortality risk progressively increased with earlier initiation of dialysis for patients aged 18?54 years (p = 0.006) and aged 55 to 64 years (p < 0.001), and no statistically significant difference was observed for patients aged 65 years or older (p = 0.12). Conclusions: Early versus later initiation of dialysis was associated with significantly higher risk of mortality in Singapore?s non-elderly population, and appeared to offer no survival advantage among the elderly. Electronic supplementary material: The online version of this article (doi:10.1186/s12882-017-0590-x) contains supplementary material, which is available to authorized users. äTiming of commencement of maintenance dialysis and mortality in young (epmc).pdf DeepDyve Pubget Overpricing