Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27854509
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Transforming Growth Factor ?1 Function in Airway Remodeling and
Hyperresponsiveness The Missing Link?
#MMPMID27854509
Ojiaku CA
; Yoo EJ
; Panettieri RA Jr
Am J Respir Cell Mol Biol
2017[Apr]; 56
(4
): 432-442
PMID27854509
show ga
The pathogenesis of asthma includes a complex interplay among airway
inflammation, hyperresponsiveness, and remodeling. Current evidence suggests that
airway structural cells, including bronchial smooth muscle cells, myofibroblasts,
fibroblasts, and epithelial cells, mediate all three aspects of asthma
pathogenesis. Although studies show a connection between airway remodeling and
changes in bronchomotor tone, the relationship between the two remains unclear.
Transforming growth factor ?1 (TGF-?1), a growth factor elevated in the airway of
patients with asthma, plays a role in airway remodeling and in the shortening of
various airway structural cells. However, the role of TGF-?1 in mediating airway
hyperresponsiveness remains unclear. In this review, we summarize the literature
addressing the role of TGF-?1 in airway remodeling and shortening. Through our
review, we aim to further elucidate the role of TGF-?1 in asthma pathogenesis and
the link between airway remodeling and airway hyperresponsiveness in asthma and
to define TGF-?1 as a potential therapeutic target for reducing asthma morbidity
and mortality.
free
free
free
