Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1165/rcmb.2016-0104OC http://scihub22266oqcxt.onion/10.1165/rcmb.2016-0104OC C5449508!5449508!28005397     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Respir+Cell+Mol+Biol 2017 ; 56 (4): 465-76 Nephropedia Template TP {{tp|p=28005397|t=2017. Tensin 1 Is Essential for Myofibroblast Differentiation and Extracellular Matrix Formation |pdf=|usr=}}{{28005397}} gab.com Text Tensin 1 Is Essential for Myofibroblast Differentiation and Extracellular Matrix Formation JO: Am J Respir Cell Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=28005397 #FOAvip Myofibroblasts, the primary effector cells that mediate matrix remodeling during pulmonary fibrosis, rapidly assemble an extracellular fibronectin matrix. Tensin (TNS) 1 is a key component of specialized cellular adhesions (fibrillar adhesions) that bind to extracellular fibronectin fibrils. We hypothesized that TNS1 may play a role in modulating myofibroblast-mediated matrix formation. We found that TNS1 expression is increased in fibroblastic foci from lungs with idiopathic pulmonary fibrosis. Transforming growth factor (TGF)-? profoundly up-regulates TNS1 expression with kinetics that parallel the expression of the myofibroblast marker, smooth muscle ?-actin. TGF-??induced TNS1 expression is dependent on signaling through the TGF-? receptor 1 and is Rho coiled-coiled kinase/actin/megakaryoblastic leukemia-1/serum response factor dependent. Small interfering RNA?mediated knockdown of TNS1 disrupted TGF-??induced myofibroblast differentiation, without affecting TGF-?/Smad signaling. In contrast, loss of TNS1 resulted in disruption of focal adhesion kinase phosphorylation, focal adhesion formation, and actin stress fiber development. Finally, TNS1 was essential for the formation of fibrillar adhesions and the assembly of nascent fibronectin and collagen matrix in myofibroblasts. In summary, our data show that TNS1 is a novel megakaryoblastic leukemia-1?dependent gene that is induced during pulmonary fibrosis. TNS1 plays an essential role in TGF-??induced myofibroblast differentiation and myofibroblast-mediated formation of extracellular fibronectin and collagen matrix. Targeted disruption of TNS1 and associated signaling may provide an avenue to inhibit tissue fibrosis. Twit Text FOAVip Tensin 1 Is Essential for Myofibroblast Differentiation and Extracellular Matrix Formation ????Am J Respir Cell Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=28005397 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28005397 #FOAvip English Wikipedia <ref>{{Cite pmid|28005397}}</ref> Tensin 1 Is Essential for Myofibroblast Differentiation and Extracellular Matrix Formation #MMPMID28005397 Bernau K; Torr EE; Evans MD; Aoki JK; Ngam CR; Sandbo N Am J Respir Cell Mol Biol 2017[Apr]; 56 (4): 465-76 PMID28005397show ga Myofibroblasts, the primary effector cells that mediate matrix remodeling during pulmonary fibrosis, rapidly assemble an extracellular fibronectin matrix. Tensin (TNS) 1 is a key component of specialized cellular adhesions (fibrillar adhesions) that bind to extracellular fibronectin fibrils. We hypothesized that TNS1 may play a role in modulating myofibroblast-mediated matrix formation. We found that TNS1 expression is increased in fibroblastic foci from lungs with idiopathic pulmonary fibrosis. Transforming growth factor (TGF)-? profoundly up-regulates TNS1 expression with kinetics that parallel the expression of the myofibroblast marker, smooth muscle ?-actin. TGF-??induced TNS1 expression is dependent on signaling through the TGF-? receptor 1 and is Rho coiled-coiled kinase/actin/megakaryoblastic leukemia-1/serum response factor dependent. Small interfering RNA?mediated knockdown of TNS1 disrupted TGF-??induced myofibroblast differentiation, without affecting TGF-?/Smad signaling. In contrast, loss of TNS1 resulted in disruption of focal adhesion kinase phosphorylation, focal adhesion formation, and actin stress fiber development. Finally, TNS1 was essential for the formation of fibrillar adhesions and the assembly of nascent fibronectin and collagen matrix in myofibroblasts. In summary, our data show that TNS1 is a novel megakaryoblastic leukemia-1?dependent gene that is induced during pulmonary fibrosis. TNS1 plays an essential role in TGF-??induced myofibroblast differentiation and myofibroblast-mediated formation of extracellular fibronectin and collagen matrix. Targeted disruption of TNS1 and associated signaling may provide an avenue to inhibit tissue fibrosis. äTensin 1 Is Essential for Myofibroblast Differentiation and Extracellu(epmc).pdf DeepDyve Pubget Overpricing