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10.1016/j.freeradbiomed.2016.11.050 http://scihub22266oqcxt.onion/10.1016/j.freeradbiomed.2016.11.050 C5449269!5449269!27915046     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Free+Radic+Biol+Med 2017 ; 107 (ä): 216-27 Nephropedia Template TP {{tp|p=27915046|t=2017. DNA Damage Related Crosstalk Between the Nucleus and Mitochondria |pdf=|usr=}}{{27915046}} gab.com Text DNA Damage Related Crosstalk Between the Nucleus and Mitochondria JO: Free Radic Biol Med http://www.kidney.de/pget.php?&tw=1&pmid=27915046 #FOAvip The electron transport chain is the primary pathway by which a cell generates energy in the form of ATP. Byproducts of this process produce reactive oxygen species that can cause damage to mitochondrial DNA. If not properly repaired, the accumulation of DNA damage can lead to mitochondrial dysfunction linked to several human disorders including neurodegenerative diseases and cancer. Mitochondria are able to combat oxidative DNA damage via repair mechanisms that are analogous to those found in the nucleus. Of the repair pathways currently reported in the mitochondria, the base excision repair pathway is the most comprehensively described. Proteins that are involved with the maintenance of mtDNA are encoded by nuclear genes and translocate to the mitochondria making signaling between the nucleus and mitochondria imperative. In this review, we discuss the current understanding of mitochondrial DNA repair mechanisms and also highlight the sensors and signaling pathways that mediate crosstalk between the nucleus and mitochondria in the event of mitochondrial stress. Twit Text FOAVip DNA Damage Related Crosstalk Between the Nucleus and Mitochondria ????Free Radic Biol Med http://www.kidney.de/pget.php?&tw=1&pmid=27915046 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27915046 #FOAvip English Wikipedia <ref>{{Cite pmid|27915046}}</ref> DNA Damage Related Crosstalk Between the Nucleus and Mitochondria #MMPMID27915046 Saki M; Prakash A Free Radic Biol Med 2017[Jun]; 107 (ä): 216-27 PMID27915046show ga The electron transport chain is the primary pathway by which a cell generates energy in the form of ATP. Byproducts of this process produce reactive oxygen species that can cause damage to mitochondrial DNA. If not properly repaired, the accumulation of DNA damage can lead to mitochondrial dysfunction linked to several human disorders including neurodegenerative diseases and cancer. Mitochondria are able to combat oxidative DNA damage via repair mechanisms that are analogous to those found in the nucleus. Of the repair pathways currently reported in the mitochondria, the base excision repair pathway is the most comprehensively described. Proteins that are involved with the maintenance of mtDNA are encoded by nuclear genes and translocate to the mitochondria making signaling between the nucleus and mitochondria imperative. In this review, we discuss the current understanding of mitochondrial DNA repair mechanisms and also highlight the sensors and signaling pathways that mediate crosstalk between the nucleus and mitochondria in the event of mitochondrial stress. äDNA Damage Related Crosstalk Between the Nucleus and Mitochondria (epmc).pdf DeepDyve Pubget Overpricing