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10.1016/j.coi.2017.01.004 http://scihub22266oqcxt.onion/10.1016/j.coi.2017.01.004 C5449256!5449256!28208102     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Opin+Immunol 2017 ; 45 (ä): 52-9 Nephropedia Template TP {{tp|p=28208102|t=2017. Oncogenic growth factor signaling mediating tumor escape from cellular immunity |pdf=|usr=}}{{28208102}} gab.com Text Oncogenic growth factor signaling mediating tumor escape from cellular immunity JO: Curr Opin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28208102 #FOAvip Unrestrained growth factor signals can promote carcinogenesis, as well as other hallmarks of cancer such as immune evasion. Our understanding of the function and complex regulation of HER family of receptors has led to the development of targeted therapeutic agents that suppress tumor growth. However, these receptors also mediate escape from recognition by the host immune system. We discuss how HER family of oncogenic receptors downregulate tumor antigen presentation and upregulate suppressive membrane-bound or soluble secreted inhibitory molecules that ultimately lead to impaired cellular immunity mediated by cytotoxic T lymphocyte (CTL) recognition. Implementing this knowledge into new therapeutic strategies to enhance tumor immunogenicity may restore effector cell mediated immune clearance of tumors and clinical efficacy of tumor-targeted immunotherapy against HER receptor overexpression. Twit Text FOAVip Oncogenic growth factor signaling mediating tumor escape from cellular immunity ????Curr Opin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28208102 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28208102 #FOAvip English Wikipedia <ref>{{Cite pmid|28208102}}</ref> Oncogenic growth factor signaling mediating tumor escape from cellular immunity #MMPMID28208102 Concha-Benavente F; Ferris RL Curr Opin Immunol 2017[Apr]; 45 (ä): 52-9 PMID28208102show ga Unrestrained growth factor signals can promote carcinogenesis, as well as other hallmarks of cancer such as immune evasion. Our understanding of the function and complex regulation of HER family of receptors has led to the development of targeted therapeutic agents that suppress tumor growth. However, these receptors also mediate escape from recognition by the host immune system. We discuss how HER family of oncogenic receptors downregulate tumor antigen presentation and upregulate suppressive membrane-bound or soluble secreted inhibitory molecules that ultimately lead to impaired cellular immunity mediated by cytotoxic T lymphocyte (CTL) recognition. Implementing this knowledge into new therapeutic strategies to enhance tumor immunogenicity may restore effector cell mediated immune clearance of tumors and clinical efficacy of tumor-targeted immunotherapy against HER receptor overexpression. äOncogenic growth factor signaling mediating tumor escape from cellular(epmc).pdf DeepDyve Pubget Overpricing