Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.coi.2017.03.007 http://scihub22266oqcxt.onion/10.1016/j.coi.2017.03.007 C5449228!5449228!28319730     free     free     free       Curr+Opin+Immunol 2017 ; 45 (ä): 112-8 Nephropedia Template TP {{tp|p=28319730|t=2017. Deconstructing the germinal center, one cell at a time |pdf=|usr=}}{{28319730}} gab.com Text Deconstructing the germinal center, one cell at a time JO: Curr Opin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28319730 #FOAvip Successful vaccination relies on driving the immune response towards high specificity, affinity and longevity. Germinal centers facilitate the evolution of antigen-specific B cells by iterative rounds of diversification, selection, and differentiation to memory and plasma cells. Experimental evidence points to B cell receptor affinity and amount of antigen presented to follicular helper T cells as main drivers of clonal evolution. Concurrent studies suggest that modifiers of cognate contact, temporal mechanisms, and stochastic factors can also shape diversity and influence differentiation to memory and plasma cells, but molecular pathways driving these selection decisions are unresolved. Due to rapid cycles of transcriptional change in the germinal center, single-cell resolution is imperative to dissect mechanisms dictating the mature antigen-specific repertoire. Future studies linking high-resolution analysis of this diverse evolving population with cellular outcome are needed to fully understand the complex mechanisms of selection driving antigen-specific humoral immunity. Twit Text FOAVip Deconstructing the germinal center, one cell at a time ????Curr Opin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28319730 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28319730 #FOAvip English Wikipedia <ref>{{Cite pmid|28319730}}</ref> Deconstructing the germinal center, one cell at a time #MMPMID28319730 Dufaud CR; McHeyzer-Williams LJ; McHeyzer-Williams MG Curr Opin Immunol 2017[Apr]; 45 (ä): 112-8 PMID28319730show ga Successful vaccination relies on driving the immune response towards high specificity, affinity and longevity. Germinal centers facilitate the evolution of antigen-specific B cells by iterative rounds of diversification, selection, and differentiation to memory and plasma cells. Experimental evidence points to B cell receptor affinity and amount of antigen presented to follicular helper T cells as main drivers of clonal evolution. Concurrent studies suggest that modifiers of cognate contact, temporal mechanisms, and stochastic factors can also shape diversity and influence differentiation to memory and plasma cells, but molecular pathways driving these selection decisions are unresolved. Due to rapid cycles of transcriptional change in the germinal center, single-cell resolution is imperative to dissect mechanisms dictating the mature antigen-specific repertoire. Future studies linking high-resolution analysis of this diverse evolving population with cellular outcome are needed to fully understand the complex mechanisms of selection driving antigen-specific humoral immunity. äDeconstructing the germinal center, one cell at a time (epmc).pdf DeepDyve Pubget Overpricing