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10.1016/j.coi.2017.03.002 http://scihub22266oqcxt.onion/10.1016/j.coi.2017.03.002 C5449227!5449227!28355576     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Opin+Immunol 2017 ; 45 (ä): 119-25 Nephropedia Template TP {{tp|p=28355576|t=2017. Role of germinal centers for the induction of broadly-reactive memory B cells |pdf=|usr=}}{{28355576}} gab.com Text Role of germinal centers for the induction of broadly-reactive memory B cells JO: Curr Opin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28355576 #FOAvip Virus-specific memory B cells (Bmem) play a crucial role in protecting against variant viruses. The ability to recognize these variant viruses, defined as antibody breadth, is achieved in Bmem populations by two very different pathways, germline-encoded cross-reactivity and affinity-driven, somatic evolution in germinal centers (GCs) for conserved viral epitopes. The latter class of broadly-reactive Bmem cells are not cross-reactive per se, but bind epitopes crucial for viral fitness. Although these conserved epitopes are often weakly immunogenic, the GC reaction is surprisingly permissive for the continued survival/proliferation of B cells that bind with low affinity or react to cryptic epitopes, increasing their chance of memory recruitment. In this review, we discuss the adaptive strategies of B-cell memory to viral antigenic variations. Twit Text FOAVip Role of germinal centers for the induction of broadly-reactive memory B cells ????Curr Opin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28355576 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28355576 #FOAvip English Wikipedia <ref>{{Cite pmid|28355576}}</ref> Role of germinal centers for the induction of broadly-reactive memory B cells #MMPMID28355576 Takahashi Y; Kelsoe G Curr Opin Immunol 2017[Apr]; 45 (ä): 119-25 PMID28355576show ga Virus-specific memory B cells (Bmem) play a crucial role in protecting against variant viruses. The ability to recognize these variant viruses, defined as antibody breadth, is achieved in Bmem populations by two very different pathways, germline-encoded cross-reactivity and affinity-driven, somatic evolution in germinal centers (GCs) for conserved viral epitopes. The latter class of broadly-reactive Bmem cells are not cross-reactive per se, but bind epitopes crucial for viral fitness. Although these conserved epitopes are often weakly immunogenic, the GC reaction is surprisingly permissive for the continued survival/proliferation of B cells that bind with low affinity or react to cryptic epitopes, increasing their chance of memory recruitment. In this review, we discuss the adaptive strategies of B-cell memory to viral antigenic variations. äRole of germinal centers for the induction of broadly-reactive memory (epmc).pdf DeepDyve Pubget Overpricing