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10.7554/eLife.24630 http://scihub22266oqcxt.onion/10.7554/eLife.24630 C5449180!5449180!28498103     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       eLife 2017 ; 6 (ä): ä Nephropedia Template TP {{tp|p=28498103|t=2017. A selectivity filter at the intracellular end of the acid-sensing ion channel pore |pdf=|usr=}}{{28498103}} gab.com Text A selectivity filter at the intracellular end of the acid-sensing ion channel pore JO: eLife http://www.kidney.de/pget.php?&tw=1&pmid=28498103 #FOAvip Increased extracellular proton concentrations during neurotransmission are converted to excitatory sodium influx by acid-sensing ion channels (ASICs). 10-fold sodium/potassium selectivity in ASICs has long been attributed to a central constriction in the channel pore, but experimental verification is lacking due to the sensitivity of this structure to conventional manipulations. Here, we explored the basis for ion selectivity by incorporating unnatural amino acids into the channel, engineering channel stoichiometry and performing free energy simulations. We observed no preference for sodium at the ?GAS belt? in the central constriction. Instead, we identified a band of glutamate and aspartate side chains at the lower end of the pore that enables preferential sodium conduction.DOI:http://dx.doi.org/10.7554/eLife.24630.001 Twit Text FOAVip A selectivity filter at the intracellular end of the acid-sensing ion channel pore ????eLife http://www.kidney.de/pget.php?&tw=1&pmid=28498103 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28498103 #FOAvip English Wikipedia <ref>{{Cite pmid|28498103}}</ref> A selectivity filter at the intracellular end of the acid-sensing ion channel pore #MMPMID28498103 Lynagh T; Flood E; Boiteux C; Wulf M; Komnatnyy VV; Colding JM; Allen TW; Pless SA eLife 2017[]; 6 (ä): ä PMID28498103show ga Increased extracellular proton concentrations during neurotransmission are converted to excitatory sodium influx by acid-sensing ion channels (ASICs). 10-fold sodium/potassium selectivity in ASICs has long been attributed to a central constriction in the channel pore, but experimental verification is lacking due to the sensitivity of this structure to conventional manipulations. Here, we explored the basis for ion selectivity by incorporating unnatural amino acids into the channel, engineering channel stoichiometry and performing free energy simulations. We observed no preference for sodium at the ?GAS belt? in the central constriction. Instead, we identified a band of glutamate and aspartate side chains at the lower end of the pore that enables preferential sodium conduction.DOI:http://dx.doi.org/10.7554/eLife.24630.001 äA selectivity filter at the intracellular end of the acid-sensing ion (epmc).pdf DeepDyve Pubget Overpricing