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10.1164/rccm.201201-0117OC http://scihub22266oqcxt.onion/10.1164/rccm.201201-0117OC C5448656!5448656!22592804     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Respir+Crit+Care+Med 2012 ; 186 (2): 170-80 Nephropedia Template TP {{tp|p=22592804|t=2012. Tetraspanin CD151 Protects against Pulmonary Fibrosis by Maintaining Epithelial Integrity |pdf=|usr=}}{{22592804}} gab.com Text Tetraspanin CD151 Protects against Pulmonary Fibrosis by Maintaining Epithelial Integrity JO: Am J Respir Crit Care Med http://www.kidney.de/pget.php?&tw=1&pmid=22592804 #FOAvip Rationale: Idiopathic pulmonary fibrosis (IPF) is a chronic pulmonary disorder of unknown etiology with few treatment options. Although tetraspanins are involved in various diseases, their roles in fibrosis have not been determined.Objectives: To investigate the role of tetraspanin CD151 in pulmonary fibrosis.Methods: CD151 knockout (KO) mice were studied by histological, biochemical, and physiological analyses and compared with wild-type mice and CD9 KO mice. Further mechanistic analyses were performed in vitro, in vivo, and on samples from patients with IPF.Measurements and Main Results: A microarray study identified an enrichment of genes involved in connective tissue disorders in the lungs of CD151 KO mice, but not in CD9 KO mice. Consistent with this, CD151 KO mice spontaneously exhibited age-related pulmonary fibrosis. Deletion of CD151 did not affect pulmonary fibroblast functions but instead degraded epithelial integrity via attenuated adhesion strength on the basement membrane; CD151-deleted alveolar epithelial cells exhibited increased ?-SMA expression with activation of p-Smad2, leading to fibrotic changes in the lungs. This loss of epithelial integrity in CD151 KO lungs was further exacerbated by intratracheal bleomycin exposure, resulting in severe fibrosis with increased mortality. We also observed decreased numbers of CD151-positive alveolar epithelial cells in patients with IPF.Conclusions: CD151 is essential for normal function of alveolar epithelial cells; loss of CD151 causes pulmonary fibrosis as a result of epithelial disintegrity. Given that CD151 may protect against fibrosis, this protein represents a novel target for the treatment of fibrotic diseases. Twit Text FOAVip Tetraspanin CD151 Protects against Pulmonary Fibrosis by Maintaining Epithelial Integrity ????Am J Respir Crit Care Med http://www.kidney.de/pget.php?&tw=1&pmid=22592804 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22592804 #FOAvip English Wikipedia <ref>{{Cite pmid|22592804}}</ref> Tetraspanin CD151 Protects against Pulmonary Fibrosis by Maintaining Epithelial Integrity #MMPMID22592804 Tsujino K; Takeda Y; Arai T; Shintani Y; Inagaki R; Saiga H; Iwasaki T; Tetsumoto S; Jin Y; Ihara S; Minami T; Suzuki M; Nagatomo I; Inoue K; Kida H; Kijima T; Ito M; Kitaichi M; Inoue Y; Tachibana I; Takeda K; Okumura M; Hemler ME; Kumanogoh A Am J Respir Crit Care Med 2012[Jul]; 186 (2): 170-80 PMID22592804show ga Rationale: Idiopathic pulmonary fibrosis (IPF) is a chronic pulmonary disorder of unknown etiology with few treatment options. Although tetraspanins are involved in various diseases, their roles in fibrosis have not been determined.Objectives: To investigate the role of tetraspanin CD151 in pulmonary fibrosis.Methods: CD151 knockout (KO) mice were studied by histological, biochemical, and physiological analyses and compared with wild-type mice and CD9 KO mice. Further mechanistic analyses were performed in vitro, in vivo, and on samples from patients with IPF.Measurements and Main Results: A microarray study identified an enrichment of genes involved in connective tissue disorders in the lungs of CD151 KO mice, but not in CD9 KO mice. Consistent with this, CD151 KO mice spontaneously exhibited age-related pulmonary fibrosis. Deletion of CD151 did not affect pulmonary fibroblast functions but instead degraded epithelial integrity via attenuated adhesion strength on the basement membrane; CD151-deleted alveolar epithelial cells exhibited increased ?-SMA expression with activation of p-Smad2, leading to fibrotic changes in the lungs. This loss of epithelial integrity in CD151 KO lungs was further exacerbated by intratracheal bleomycin exposure, resulting in severe fibrosis with increased mortality. We also observed decreased numbers of CD151-positive alveolar epithelial cells in patients with IPF.Conclusions: CD151 is essential for normal function of alveolar epithelial cells; loss of CD151 causes pulmonary fibrosis as a result of epithelial disintegrity. Given that CD151 may protect against fibrosis, this protein represents a novel target for the treatment of fibrotic diseases. äTetraspanin CD151 Protects against Pulmonary Fibrosis by Maintaining E(epmc).pdf DeepDyve Pubget Overpricing