Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1111/cas.13228 http://scihub22266oqcxt.onion/10.1111/cas.13228 C5448613!5448613!28266780     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Sci 2017 ; 108 (5): 831-7 Nephropedia Template TP {{tp|p=28266780|t=2017. Recent advances in genetic modification of adenovirus vectors for cancer treatment |pdf=|usr=}}{{28266780}} gab.com Text Recent advances in genetic modification of adenovirus vectors for cancer treatment JO: Cancer Sci http://www.kidney.de/pget.php?&tw=1&pmid=28266780 #FOAvip Adenoviruses are widely used to deliver genes to a variety of cell types and have been used in a number of clinical trials for gene therapy and oncolytic virotherapy. However, several concerns must be addressed for the clinical use of adenovirus vectors. Selective delivery of a therapeutic gene by adenovirus vectors to target cancer is precluded by the widespread distribution of the primary cellular receptors. The systemic administration of adenoviruses results in hepatic tropism independent of the primary receptors. Adenoviruses induce strong innate and acquired immunity in vivo. Furthermore, several modifications to these vectors are necessary to enhance their oncolytic activity and ensure patient safety. As such, the adenovirus genome has been engineered to overcome these problems. The first part of the present review outlines recent progress in the genetic modification of adenovirus vectors for cancer treatment. In addition, several groups have recently developed cancer?targeting adenovirus vectors by using libraries that display random peptides on a fiber knob. Pancreatic cancer?targeting sequences have been isolated, and these oncolytic vectors have been shown by our group to be associated with a higher gene transduction efficiency and more potent oncolytic activity in cell lines, murine models, and surgical specimens of pancreatic cancer. In the second part of this review, we explain that combining cancer?targeting strategies can be a promising approach to increase the clinical usefulness of oncolytic adenovirus vectors. Twit Text FOAVip Recent advances in genetic modification of adenovirus vectors for cancer treatment ????Cancer Sci http://www.kidney.de/pget.php?&tw=1&pmid=28266780 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28266780 #FOAvip English Wikipedia <ref>{{Cite pmid|28266780}}</ref> Recent advances in genetic modification of adenovirus vectors for cancer treatment #MMPMID28266780 Yamamoto Y; Nagasato M; Yoshida T; Aoki K Cancer Sci 2017[May]; 108 (5): 831-7 PMID28266780show ga Adenoviruses are widely used to deliver genes to a variety of cell types and have been used in a number of clinical trials for gene therapy and oncolytic virotherapy. However, several concerns must be addressed for the clinical use of adenovirus vectors. Selective delivery of a therapeutic gene by adenovirus vectors to target cancer is precluded by the widespread distribution of the primary cellular receptors. The systemic administration of adenoviruses results in hepatic tropism independent of the primary receptors. Adenoviruses induce strong innate and acquired immunity in vivo. Furthermore, several modifications to these vectors are necessary to enhance their oncolytic activity and ensure patient safety. As such, the adenovirus genome has been engineered to overcome these problems. The first part of the present review outlines recent progress in the genetic modification of adenovirus vectors for cancer treatment. In addition, several groups have recently developed cancer?targeting adenovirus vectors by using libraries that display random peptides on a fiber knob. Pancreatic cancer?targeting sequences have been isolated, and these oncolytic vectors have been shown by our group to be associated with a higher gene transduction efficiency and more potent oncolytic activity in cell lines, murine models, and surgical specimens of pancreatic cancer. In the second part of this review, we explain that combining cancer?targeting strategies can be a promising approach to increase the clinical usefulness of oncolytic adenovirus vectors. äRecent advances in genetic modification of adenovirus vectors for canc(epmc).pdf DeepDyve Pubget Overpricing