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10.1073/pnas.1611506114 http://scihub22266oqcxt.onion/10.1073/pnas.1611506114 C5448213!5448213!28490503     free     free     free Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2017 ; 114 (21): 5455-60 Nephropedia Template TP {{tp|p=28490503|t=2017. Entropic forces drive self-organization and membrane fusion by SNARE proteins |pdf=|usr=}}{{28490503}} gab.com Text Entropic forces drive self-organization and membrane fusion by SNARE proteins JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28490503 #FOAvip Secretion of neurotransmitters and hormones depends on membrane fusion, accomplished by a cellular fusion machinery whose core components are SNARE proteins. Several vesicle-associated v-SNAREs form SNAREpin complexes with target membrane-associated t-SNAREs, but how they cooperate to catalyze fusion is unknown. Using highly coarse-grained simulations, we found that steric interactions spontaneously organized SNAREpins into circular clusters, expanded the clusters, and forced membranes together. These are entropic effects, reminiscent of cooperative transitions in solutions of rod-like molecules. The rate of fusion was controlled by the number of SNAREs, because more SNAREs generated greater entropic forces. Given ?70 v-SNAREs available per synaptic vesicle, entropic cooperativity among SNAREpins may underlie the sub-millisecond timescale of neurotransmitter release. Twit Text FOAVip Entropic forces drive self-organization and membrane fusion by SNARE proteins ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28490503 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28490503 #FOAvip English Wikipedia <ref>{{Cite pmid|28490503}}</ref> Entropic forces drive self-organization and membrane fusion by SNARE proteins #MMPMID28490503 Mostafavi H; Thiyagarajan S; Stratton BS; Karatekin E; Warner JM; Rothman JE; O?Shaughnessy B Proc Natl Acad Sci U S A 2017[May]; 114 (21): 5455-60 PMID28490503show ga Secretion of neurotransmitters and hormones depends on membrane fusion, accomplished by a cellular fusion machinery whose core components are SNARE proteins. Several vesicle-associated v-SNAREs form SNAREpin complexes with target membrane-associated t-SNAREs, but how they cooperate to catalyze fusion is unknown. Using highly coarse-grained simulations, we found that steric interactions spontaneously organized SNAREpins into circular clusters, expanded the clusters, and forced membranes together. These are entropic effects, reminiscent of cooperative transitions in solutions of rod-like molecules. The rate of fusion was controlled by the number of SNAREs, because more SNAREs generated greater entropic forces. Given ?70 v-SNAREs available per synaptic vesicle, entropic cooperativity among SNAREpins may underlie the sub-millisecond timescale of neurotransmitter release. äEntropic forces drive self-organization and membrane fusion by SNARE p(epmc).pdf DeepDyve Pubget Overpricing