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10.1073/pnas.1614291114 http://scihub22266oqcxt.onion/10.1073/pnas.1614291114 C5448208!5448208!28490501     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2017 ; 114 (21): E4175-83 Nephropedia Template TP {{tp|p=28490501|t=2017. Dynamic microtubules regulate cellular contractility during T-cell activation |pdf=|usr=}}{{28490501}} gab.com Text Dynamic microtubules regulate cellular contractility during T-cell activation JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28490501 #FOAvip T-cell activation is an essential event in the adaptive immune response to fight against infections. T cells were recently shown to be mechanosensitive, and to exert forces actively on the opposing antigen-presenting cell during activation. However, the molecular basis of force generation by T cells is poorly understood. Here, we report a molecular mechanism that involves the T-cell microtubule (MT) and actomyosin cytoskeletons, which interact through Rho GTPase activity. Our study highlights the role played by the MT cytoskeleton in regulating actomyosin-generated forces, which play a key role in T-cell activation. Twit Text FOAVip Dynamic microtubules regulate cellular contractility during T-cell activation ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28490501 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28490501 #FOAvip English Wikipedia <ref>{{Cite pmid|28490501}}</ref> Dynamic microtubules regulate cellular contractility during T-cell activation #MMPMID28490501 Hui KL; Upadhyaya A Proc Natl Acad Sci U S A 2017[May]; 114 (21): E4175-83 PMID28490501show ga T-cell activation is an essential event in the adaptive immune response to fight against infections. T cells were recently shown to be mechanosensitive, and to exert forces actively on the opposing antigen-presenting cell during activation. However, the molecular basis of force generation by T cells is poorly understood. Here, we report a molecular mechanism that involves the T-cell microtubule (MT) and actomyosin cytoskeletons, which interact through Rho GTPase activity. Our study highlights the role played by the MT cytoskeleton in regulating actomyosin-generated forces, which play a key role in T-cell activation. äDynamic microtubules regulate cellular contractility during T-cell act(epmc).pdf DeepDyve Pubget Overpricing