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10.1073/pnas.1705527114 http://scihub22266oqcxt.onion/10.1073/pnas.1705527114 C5448194!5448194!28490498     free     free     free Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2017 ; 114 (21): 5479-84 Nephropedia Template TP {{tp|p=28490498|t=2017. Shelterin components mediate genome reorganization in response to replication stress |pdf=|usr=}}{{28490498}} gab.com Text Shelterin components mediate genome reorganization in response to replication stress JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28490498 #FOAvip Genome organization affects many critical nuclear functions. Notably, the nuclear periphery has emerged as a specialized compartment for the regulation of transcription, replication, and DNA damage repair activities. Here, we find that cells carrying a mutation in the broadly distributed DNA-binding protein Sap1 experience replication stress and genome instability and undergo a genome reorganization featuring new contacts between chromosome arms and telomeres. These prominent new interactions are mediated by the Taz1?Shelterin telomere protection complex and include specific chromosome arm regions containing replication origins bound by Taz1. Our findings uncover an unexpected role for Shelterin in mediating genome reorganization in cells undergoing replication stress. Twit Text FOAVip Shelterin components mediate genome reorganization in response to replication stress ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28490498 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28490498 #FOAvip English Wikipedia <ref>{{Cite pmid|28490498}}</ref> Shelterin components mediate genome reorganization in response to replication stress #MMPMID28490498 Mizuguchi T; Taneja N; Matsuda E; Belton JM; FitzGerald P; Dekker J; Grewal SIS Proc Natl Acad Sci U S A 2017[May]; 114 (21): 5479-84 PMID28490498show ga Genome organization affects many critical nuclear functions. Notably, the nuclear periphery has emerged as a specialized compartment for the regulation of transcription, replication, and DNA damage repair activities. Here, we find that cells carrying a mutation in the broadly distributed DNA-binding protein Sap1 experience replication stress and genome instability and undergo a genome reorganization featuring new contacts between chromosome arms and telomeres. These prominent new interactions are mediated by the Taz1?Shelterin telomere protection complex and include specific chromosome arm regions containing replication origins bound by Taz1. Our findings uncover an unexpected role for Shelterin in mediating genome reorganization in cells undergoing replication stress. äShelterin components mediate genome reorganization in response to repl(epmc).pdf DeepDyve Pubget Overpricing