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10.1074/jbc.R116.767434 http://scihub22266oqcxt.onion/10.1074/jbc.R116.767434 C5448086!5448086!28389557     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Biol+Chem 2017 ; 292 (21): 8569-76 Nephropedia Template TP {{tp|p=28389557|t=2017. Glucuronides in the gut: Sugar-driven symbioses between microbe and host |pdf=|usr=}}{{28389557}} gab.com Text Glucuronides in the gut: Sugar-driven symbioses between microbe and host JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=28389557 #FOAvip The intestinal milieu is astonishingly complex and home to a constantly changing mixture of small and large molecules, along with an abundance of bacteria, viral particles, and eukaryotic cells. Such complexity makes it difficult to develop testable molecular hypotheses regarding host-microbe interactions. Fortunately, mammals and their associated gastrointestinal (GI) microbes contain complementary systems that are ideally suited for mechanistic studies. Mammalian systems inactivate endobiotic and xenobiotic compounds by linking them to a glucuronic acid sugar for GI excretion. In the GI tract, the microbiota express ?-glucuronidase enzymes that remove the glucuronic acid as a carbon source, effectively reversing the actions of mammalian inactivation. Thus, by probing the actions of microbial ?-glucuronidases, and by understanding which substrate glucuronides they process, molecular insights into mammalian-microbial symbioses may be revealed amid the complexity of the intestinal tract. Here, we focus on glucuronides in the gut and the microbial proteins that process them. Twit Text FOAVip Glucuronides in the gut: Sugar-driven symbioses between microbe and host ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=28389557 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28389557 #FOAvip English Wikipedia <ref>{{Cite pmid|28389557}}</ref> Glucuronides in the gut: Sugar-driven symbioses between microbe and host #MMPMID28389557 Pellock SJ; Redinbo MR J Biol Chem 2017[May]; 292 (21): 8569-76 PMID28389557show ga The intestinal milieu is astonishingly complex and home to a constantly changing mixture of small and large molecules, along with an abundance of bacteria, viral particles, and eukaryotic cells. Such complexity makes it difficult to develop testable molecular hypotheses regarding host-microbe interactions. Fortunately, mammals and their associated gastrointestinal (GI) microbes contain complementary systems that are ideally suited for mechanistic studies. Mammalian systems inactivate endobiotic and xenobiotic compounds by linking them to a glucuronic acid sugar for GI excretion. In the GI tract, the microbiota express ?-glucuronidase enzymes that remove the glucuronic acid as a carbon source, effectively reversing the actions of mammalian inactivation. Thus, by probing the actions of microbial ?-glucuronidases, and by understanding which substrate glucuronides they process, molecular insights into mammalian-microbial symbioses may be revealed amid the complexity of the intestinal tract. Here, we focus on glucuronides in the gut and the microbial proteins that process them. äGlucuronides in the gut: Sugar-driven symbioses between microbe and ho(epmc).pdf DeepDyve Pubget Overpricing