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10.1074/jbc.R116.765388 http://scihub22266oqcxt.onion/10.1074/jbc.R116.765388 C5448085!5448085!28389555     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Biol+Chem 2017 ; 292 (21): 8560-8 Nephropedia Template TP {{tp|p=28389555|t=2017. Targeting of microbe-derived metabolites to improve human health: The next frontier for drug discovery |pdf=|usr=}}{{28389555}} gab.com Text Targeting of microbe-derived metabolites to improve human health: The next frontier for drug discovery JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=28389555 #FOAvip Recent advances in metabolomic and genome mining approaches have uncovered a poorly understood metabolome that originates solely or in part from bacterial enzyme sources. Whether living on exposed surfaces or within our intestinal tract, our microbial inhabitants produce a remarkably diverse set of natural products and small molecule metabolites that can impact human health and disease. Highlighted here, the gut microbe-derived metabolite trimethylamine N-oxide has been causally linked to the development of cardiovascular diseases. Recent studies reveal drugging this pathway can inhibit atherosclerosis development in mice. Building on this example, we discuss challenges and untapped potential of targeting bacterial enzymology for improvements in human health. Twit Text FOAVip Targeting of microbe-derived metabolites to improve human health: The next frontier for drug discovery ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=28389555 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28389555 #FOAvip English Wikipedia <ref>{{Cite pmid|28389555}}</ref> Targeting of microbe-derived metabolites to improve human health: The next frontier for drug discovery #MMPMID28389555 Brown JM; Hazen SL J Biol Chem 2017[May]; 292 (21): 8560-8 PMID28389555show ga Recent advances in metabolomic and genome mining approaches have uncovered a poorly understood metabolome that originates solely or in part from bacterial enzyme sources. Whether living on exposed surfaces or within our intestinal tract, our microbial inhabitants produce a remarkably diverse set of natural products and small molecule metabolites that can impact human health and disease. Highlighted here, the gut microbe-derived metabolite trimethylamine N-oxide has been causally linked to the development of cardiovascular diseases. Recent studies reveal drugging this pathway can inhibit atherosclerosis development in mice. Building on this example, we discuss challenges and untapped potential of targeting bacterial enzymology for improvements in human health. äTargeting of microbe-derived metabolites to improve human health: The (epmc).pdf DeepDyve Pubget Overpricing