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2017 ; 6
(5
): ä Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Role of Autoantibodies in the Diagnosis of Connective-Tissue Disease ILD
(CTD-ILD) and Interstitial Pneumonia with Autoimmune Features (IPAF)
#MMPMID28471413
Jee AS
; Adelstein S
; Bleasel J
; Keir GJ
; Nguyen M
; Sahhar J
; Youssef P
; Corte TJ
J Clin Med
2017[May]; 6
(5
): ä PMID28471413
show ga
The diagnosis of interstitial lung disease (ILD) requires meticulous evaluation
for an underlying connective tissue disease (CTD), with major implications for
prognosis and management. CTD associated ILD (CTD-ILD) occurs most commonly in
the context of an established CTD, but can be the first and/or only manifestation
of an occult CTD or occur in patients who have features suggestive of an
autoimmune process, but not meeting diagnostic criteria for a defined
CTD-recently defined as "interstitial pneumonia with autoimmune features" (IPAF).
The detection of specific autoantibodies serves a critical role in the diagnosis
of CTD-ILD, but there remains a lack of data to guide clinical practice including
which autoantibodies should be tested on initial assessment and when or in whom
serial testing should be performed. The implications of detecting autoantibodies
in patients with IPAF on disease behaviour and management remain unknown. The
evaluation of CTD-ILD is challenging due to the heterogeneity of presentations
and types of CTD and ILD that may be encountered, and thus it is imperative that
immunologic tests are interpreted in conjunction with a detailed rheumatologic
history and examination and multidisciplinary collaboration between respiratory
physicians, rheumatologists, immunologists, radiologists and pathologists.
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