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2017 ; 120
(11
): 1825-1841
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English Wikipedia
AMP-Activated Protein Kinase: An Ubiquitous Signaling Pathway With Key Roles in
the Cardiovascular System
#MMPMID28546359
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; Hardie DG
Circ Res
2017[May]; 120
(11
): 1825-1841
PMID28546359
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The AMP-activated protein kinase (AMPK) is a key regulator of cellular and
whole-body energy homeostasis, which acts to restore energy homoeostasis whenever
cellular energy charge is depleted. Over the last 2 decades, it has become
apparent that AMPK regulates several other cellular functions and has specific
roles in cardiovascular tissues, acting to regulate cardiac metabolism and
contractile function, as well as promoting anticontractile, anti-inflammatory,
and antiatherogenic actions in blood vessels. In this review, we discuss the role
of AMPK in the cardiovascular system, including the molecular basis of mutations
in AMPK that alter cardiac physiology and the proposed mechanisms by which AMPK
regulates vascular function under physiological and pathophysiological
conditions.