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2017 ; 32
(3
): 195-200
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The Role of Insulin Therapy in Correcting Hepcidin Levels in Patients with Type 2
Diabetes Mellitus
#MMPMID28584599
Vela D
; Leshoski J
; Gjorgievska ES
; Hadzi-Petrushev N
; Jakupaj M
; Sopi RB
; Mladenov M
Oman Med J
2017[May]; 32
(3
): 195-200
PMID28584599
show ga
OBJECTIVES: Iron overload can cause or contribute to the pathogenesis of type 2
diabetes mellitus (T2DM), but how the major parameters of iron metabolism change
in different settings of diabetes are still unclear. The aim of this study was to
determine the relationship between iron, ferritin, and hepcidin levels in
diabetic patients and the effect of insulin treatment. METHODS: The study
included 80 subjects, 60 with T2DM and 20 without (control group). Serum
hepcidin, insulin, ferritin, and iron levels were determined as well as other
clinical parameters. The associations between these parameters were analyzed
between both groups. RESULTS: Hepcidin levels expressed as mean± standard
deviation between groups showed no significant changes (14.4±6.7 ng/mL for the
control group, and 18.4±7.9 ng/mL for patients with diabetes, p = 0.069).
Parameters of iron metabolism showed modest correlation with the parameters of
glucose metabolism. However, the correlation between ferritin and insulin in both
groups was statistically significant (p = 0.032; ? = 0.480 vs. p = 0.011; ? =
0.328). CONCLUSIONS: Our study showed that hepcidin levels in patients with T2DM
on insulin therapy do not change, which might be a result of treatment with
insulin. In this context, insulin treatment can be used as a novel method for
correction of hepcidin levels. By correcting hepcidin levels, we can prevent
cellular iron overload and reduce the risk of diabetes.