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10.1016/j.gde.2017.02.007 http://scihub22266oqcxt.onion/10.1016/j.gde.2017.02.007 C5447501!5447501!28359978     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Opin+Genet+Dev 2017 ; 43 (ä): 110-9 Nephropedia Template TP {{tp|p=28359978|t=2017. Transcription factor?DNA binding: beyond binding site motifs |pdf=|usr=}}{{28359978}} gab.com Text Transcription factor DNA binding: beyond binding site motifs JO: Curr Opin Genet Dev http://www.kidney.de/pget.php?&tw=1&pmid=28359978 #FOAvip Sequence-specific transcription factors (TFs) regulate gene expression by binding to cis-regulatory elements in promoter and enhancer DNA. While studies of TF?DNA binding have focused on TFs' intrinsic preferences for primary nucleotide sequence motifs, recent studies have elucidated additional layers of complexity that modulate TF?DNA binding. In this review, we discuss technological developments for identifying TF binding preferences and highlight recent discoveries that elaborate how TF interactions, local DNA structure, and genomic features influence TF?DNA binding. We highlight novel approaches for characterizing functional binding site motifs that promise to inform our understanding of how TF binding controls gene expression and ultimately contributes to phenotype. Twit Text FOAVip Transcription factor DNA binding: beyond binding site motifs ????Curr Opin Genet Dev http://www.kidney.de/pget.php?&tw=1&pmid=28359978 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28359978 #FOAvip English Wikipedia <ref>{{Cite pmid|28359978}}</ref> Transcription factor?DNA binding: beyond binding site motifs #MMPMID28359978 Inukai S; Kock KH; Bulyk ML Curr Opin Genet Dev 2017[Apr]; 43 (ä): 110-9 PMID28359978show ga Sequence-specific transcription factors (TFs) regulate gene expression by binding to cis-regulatory elements in promoter and enhancer DNA. While studies of TF?DNA binding have focused on TFs' intrinsic preferences for primary nucleotide sequence motifs, recent studies have elucidated additional layers of complexity that modulate TF?DNA binding. In this review, we discuss technological developments for identifying TF binding preferences and highlight recent discoveries that elaborate how TF interactions, local DNA structure, and genomic features influence TF?DNA binding. We highlight novel approaches for characterizing functional binding site motifs that promise to inform our understanding of how TF binding controls gene expression and ultimately contributes to phenotype. äTranscription factor?DNA binding: beyond binding site motifs (epmc).pdf DeepDyve Pubget Overpricing