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10.1016/j.conb.2016.12.002 http://scihub22266oqcxt.onion/10.1016/j.conb.2016.12.002 C5447486!5447486 !28024185     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28024185 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Curr+Opin+Neurobiol 2017 ; 43 (?): 48-55 Nephropedia Template TP {{tp|p=28024185 |t=2017. In the loop: how chromatin topology links genome structure to function in mechanisms underlying learning and memory |pdf=|usr=}}{{28024185 }} gab.com Text In the loop: how chromatin topology links genome structure to function in mechanisms underlying learning and memory JO: Curr Opin Neurobiol http://www.kidney.de/pget.php?&tw=1&pmid=28024185 #FOAvip Different aspects of learning, memory, and cognition are regulated by epigenetic mechanisms such as covalent DNA modifications and histone post-translational modifications. More recently, the modulation of chromatin architecture and nuclear organization is emerging as a key factor in dynamic transcriptional regulation of the post-mitotic neuron. For instance, neuronal activity induces relocalization of gene loci to 'transcription factories', and specific enhancer-promoter looping contacts allow for precise transcriptional regulation. Moreover, neuronal activity-dependent DNA double-strand break formation in the promoter of immediate early genes appears to overcome topological constraints on transcription. Together, these findings point to a critical role for genome topology in integrating dynamic environmental signals to define precise spatiotemporal gene expression programs supporting cognitive processes. Twit Text FOAVip In the loop: how chromatin topology links genome structure to function in mechanisms underlying learning and memory ????Curr Opin Neurobiol http://www.kidney.de/pget.php?&tw=1&pmid=28024185 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28024185 #FOAvip English Wikipedia <ref>{{Cite pmid|28024185 }}</ref> In the loop: how chromatin topology links genome structure to function in mechanisms underlying learning and memory #MMPMID28024185 Watson LA ; Tsai LH Curr Opin Neurobiol 2017[Apr]; 43 (?): 48-55 PMID28024185 show ga Different aspects of learning, memory, and cognition are regulated by epigenetic mechanisms such as covalent DNA modifications and histone post-translational modifications. More recently, the modulation of chromatin architecture and nuclear organization is emerging as a key factor in dynamic transcriptional regulation of the post-mitotic neuron. For instance, neuronal activity induces relocalization of gene loci to 'transcription factories', and specific enhancer-promoter looping contacts allow for precise transcriptional regulation. Moreover, neuronal activity-dependent DNA double-strand break formation in the promoter of immediate early genes appears to overcome topological constraints on transcription. Together, these findings point to a critical role for genome topology in integrating dynamic environmental signals to define precise spatiotemporal gene expression programs supporting cognitive processes. |*Epigenesis, Genetic [MESH] |*Genome [MESH] |Chromatin/*chemistry [MESH] |Histones/genetics [MESH] |Humans [MESH] |Learning/*physiology [MESH]In the loop: how chromatin topology links genome structure to function(epmc).pdf DeepDyve Pubget Overpricing