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10.3389/fpls.2017.00893

http://scihub22266oqcxt.onion/10.3389/fpls.2017.00893
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C5446985!5446985!28611808
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suck abstract from ncbi


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pmid28611808      Front+Plant+Sci 2017 ; 8 (ä): ä
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  • Network Analysis Reveals a Common Host?Pathogen Interaction Pattern in Arabidopsis Immune Responses #MMPMID28611808
  • Li H; Zhou Y; Zhang Z
  • Front Plant Sci 2017[]; 8 (ä): ä PMID28611808show ga
  • Many plant pathogens secrete virulence effectors into host cells to target important proteins in host cellular network. However, the dynamic interactions between effectors and host cellular network have not been fully understood. Here, an integrative network analysis was conducted by combining Arabidopsis thaliana protein?protein interaction network, known targets of Pseudomonas syringae and Hyaloperonospora arabidopsidis effectors, and gene expression profiles in the immune response. In particular, we focused on the characteristic network topology of the effector targets and differentially expressed genes (DEGs). We found that effectors tended to manipulate key network positions with higher betweenness centrality. The effector targets, especially those that are common targets of an individual effector, tended to be clustered together in the network. Moreover, the distances between the effector targets and DEGs increased over time during infection. In line with this observation, pathogen-susceptible mutants tended to have more DEGs surrounding the effector targets compared with resistant mutants. Our results suggest a common plant?pathogen interaction pattern at the cellular network level, where pathogens employ potent local impact mode to interfere with key positions in the host network, and plant organizes an in-depth defense by sequentially activating genes distal to the effector targets.
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