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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Am+J+Cancer+Res
2017 ; 7
(5
): 1054-1067
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CEBPA-mediated upregulation of the lncRNA PLIN2 promotes the development of
chronic myelogenous leukemia via the GSK3 and Wnt/?-catenin signaling pathways
#MMPMID28560057
Sun C
; Luan S
; Zhang G
; Wang N
; Shao H
; Luan C
Am J Cancer Res
2017[]; 7
(5
): 1054-1067
PMID28560057
show ga
Accumulating evidence has shown that long noncoding RNAs (lncRNAs) are
significant regulators of multiple cellular processes, including the development
of chronic myelocytic leukemia (CML). However, the mechanism of how the lncRNA
PLIN2 affects CML development remains unclear. In this study, we aimed to
investigate the potential roles of CEBPA-mediated upregulation of PLIN2 in the
process of CML development by regulating the GSK3 and Wnt/?-catenin signaling
pathways. We found that both CEBPA and PLIN2 were expressed at significantly
higher levels in CML. Simultaneously, we found that CEBPA upregulated the
expression of PLIN2 and that there was a positive correlation between CEBPA and
PLIN2 in CML patients. CEBPA promoted the progression of CML by upregulating
PLIN2. We also found that PLIN2 increased the expression levels of AKT, p-AKT,
GSK-3?, ?-catenin and Axin2/Conductin as well as promoted the progression of CML
via the GSK3 and Wnt/?-catenin signaling pathways in vitro. Furthermore, we found
that CEBPA-mediated upregulation of PLIN2 expression promotes tumor growth via
GSK3 and Wnt/?-catenin signaling in vivo. Therefore, our study provided a new
theoretical basis for CML treatment through the CEBPA/PLIN2 axis.