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10.1371/journal.pone.0175292 http://scihub22266oqcxt.onion/10.1371/journal.pone.0175292 C5446112!5446112 !28552948     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28552948 &cmd=llinks): Failed to open stream: HTTP request failed! 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Association of gain-of-function EPHX2 polymorphism Lys55Arg with acute kidney injury following cardiac surgery |pdf=|usr=}}{{28552948 }} gab.com Text Association of gain-of-function EPHX2 polymorphism Lys55Arg with acute kidney injury following cardiac surgery JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=28552948 #FOAvip Twenty to thirty percent of patients undergoing cardiac surgery develop acute kidney injury (AKI). In mice, inhibition of soluble epoxide hydrolase (sEH) attenuates renal injury following ischemia-reperfusion. We tested the hypothesis that functional variants of EPHX2, encoding sEH, are associated with AKI after cardiac surgery. We genotyped patients in two independent cardiac surgery cohorts for functional EPHX2 polymorphisms, Lys55Arg and Arg287Gln, and determined AKI using Acute Kidney Injury Network criteria. The 287Gln variant was not associated with AKI. In the discovery cohort, the gain-of-function 55Arg variant was associated with an increased incidence of AKI in univariate (p = 0.03) and multivariable (p = 0.04) analyses. In white patients without chronic kidney disease (CKD), the 55Arg variant was independently associated with AKI with an OR of 2.04 (95% CI 0.95-4.42) for 55Arg heterozygotes and 31.53 (1.57-633.19) for homozygotes (p = 0.02), after controlling for age, sex, body mass index, baseline estimated glomerular filtration rate, and use of cardiopulmonary bypass. These findings were replicated in the second cardiac surgery cohort. 12,13- and total- dihydroxyoctadecanoic acids (DiHOME): epoxyoctadecanoic acids (EpOME) ratios were increased in EPHX2 55Arg variant carriers, consistent with increased hydrolase activity. The EPHX2 Lys55Arg polymorphism is associated with AKI following cardiac surgery in patients without preexisting CKD. Pharmacological strategies to decrease sEH activity might decrease postoperative AKI. Twit Text FOAVip Association of gain-of-function EPHX2 polymorphism Lys55Arg with acute kidney injury following cardiac surgery ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=28552948 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28552948 #FOAvip English Wikipedia <ref>{{Cite pmid|28552948 }}</ref> Association of gain-of-function EPHX2 polymorphism Lys55Arg with acute kidney injury following cardiac surgery #MMPMID28552948 Shuey MM ; Billings FT 4th ; Wei S ; Milne GL ; Nian H ; Yu C ; Brown NJ PLoS One 2017[]; 12 (5 ): e0175292 PMID28552948 show ga Twenty to thirty percent of patients undergoing cardiac surgery develop acute kidney injury (AKI). In mice, inhibition of soluble epoxide hydrolase (sEH) attenuates renal injury following ischemia-reperfusion. We tested the hypothesis that functional variants of EPHX2, encoding sEH, are associated with AKI after cardiac surgery. We genotyped patients in two independent cardiac surgery cohorts for functional EPHX2 polymorphisms, Lys55Arg and Arg287Gln, and determined AKI using Acute Kidney Injury Network criteria. The 287Gln variant was not associated with AKI. In the discovery cohort, the gain-of-function 55Arg variant was associated with an increased incidence of AKI in univariate (p = 0.03) and multivariable (p = 0.04) analyses. In white patients without chronic kidney disease (CKD), the 55Arg variant was independently associated with AKI with an OR of 2.04 (95% CI 0.95-4.42) for 55Arg heterozygotes and 31.53 (1.57-633.19) for homozygotes (p = 0.02), after controlling for age, sex, body mass index, baseline estimated glomerular filtration rate, and use of cardiopulmonary bypass. These findings were replicated in the second cardiac surgery cohort. 12,13- and total- dihydroxyoctadecanoic acids (DiHOME): epoxyoctadecanoic acids (EpOME) ratios were increased in EPHX2 55Arg variant carriers, consistent with increased hydrolase activity. The EPHX2 Lys55Arg polymorphism is associated with AKI following cardiac surgery in patients without preexisting CKD. Pharmacological strategies to decrease sEH activity might decrease postoperative AKI. |*Polymorphism, Genetic [MESH] |Acute Kidney Injury/*etiology/genetics/physiopathology [MESH] |Aged [MESH] |Cohort Studies [MESH] |Coronary Artery Bypass/*adverse effects [MESH] |Eicosapentaenoic Acid/blood/metabolism [MESH] |Epoxide Hydrolases/chemistry/*genetics [MESH] |Female [MESH] |Genotype [MESH] |Glomerular Filtration Rate [MESH] |Humans [MESH] |Incidence [MESH] |Lysine/*genetics [MESH] |Male [MESH]Association of gain-of-function EPHX2 polymorphism Lys55Arg with acute(epmc).pdf DeepDyve Pubget Overpricing