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10.1158/0008-5472.CAN-16-2589 http://scihub22266oqcxt.onion/10.1158/0008-5472.CAN-16-2589 C5445903!5445903 !28249899     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28249899 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cancer+Res 2017 ; 77 (9 ): 2387-2400 Nephropedia Template TP {{tp|p=28249899 |t=2017. Krüppel-like Transcription Factor KLF10 Suppresses TGF?-Induced Epithelial-to-Mesenchymal Transition via a Negative Feedback Mechanism |pdf=|usr=}}{{28249899 }} gab.com Text Krüppel-like Transcription Factor KLF10 Suppresses TGF -Induced Epithelial-to-Mesenchymal Transition via a Negative Feedback Mechanism JO: Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=28249899 #FOAvip TGF?-SMAD signaling exerts a contextual effect that suppresses malignant growth early in epithelial tumorigenesis but promotes metastasis at later stages. Longstanding challenges in resolving this functional dichotomy may uncover new strategies to treat advanced carcinomas. The Krüppel-like transcription factor, KLF10, is a pivotal effector of TGF?/SMAD signaling that mediates antiproliferative effects of TGF?. In this study, we show how KLF10 opposes the prometastatic effects of TGF? by limiting its ability to induce epithelial-to-mesenchymal transition (EMT). KLF10 depletion accentuated induction of EMT as assessed by multiple metrics. KLF10 occupied GC-rich sequences in the promoter region of the EMT-promoting transcription factor SLUG/SNAI2, repressing its transcription by recruiting HDAC1 and licensing the removal of activating histone acetylation marks. In clinical specimens of lung adenocarcinoma, low KLF10 expression associated with decreased patient survival, consistent with a pivotal role for KLF10 in distinguishing the antiproliferative versus prometastatic functions of TGF?. Our results establish that KLF10 functions to suppress TGF?-induced EMT, establishing a molecular basis for the dichotomy of TGF? function during tumor progression. Cancer Res; 77(9); 2387-400. ©2017 AACR. Twit Text FOAVip Krüppel-like Transcription Factor KLF10 Suppresses TGF -Induced Epithelial-to-Mesenchymal Transition via a Negative Feedback Mechanism ????Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=28249899 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28249899 #FOAvip English Wikipedia <ref>{{Cite pmid|28249899 }}</ref> Krüppel-like Transcription Factor KLF10 Suppresses TGF?-Induced Epithelial-to-Mesenchymal Transition via a Negative Feedback Mechanism #MMPMID28249899 Mishra VK ; Subramaniam M ; Kari V ; Pitel KS ; Baumgart SJ ; Naylor RM ; Nagarajan S ; Wegwitz F ; Ellenrieder V ; Hawse JR ; Johnsen SA Cancer Res 2017[May]; 77 (9 ): 2387-2400 PMID28249899 show ga TGF?-SMAD signaling exerts a contextual effect that suppresses malignant growth early in epithelial tumorigenesis but promotes metastasis at later stages. Longstanding challenges in resolving this functional dichotomy may uncover new strategies to treat advanced carcinomas. The Krüppel-like transcription factor, KLF10, is a pivotal effector of TGF?/SMAD signaling that mediates antiproliferative effects of TGF?. In this study, we show how KLF10 opposes the prometastatic effects of TGF? by limiting its ability to induce epithelial-to-mesenchymal transition (EMT). KLF10 depletion accentuated induction of EMT as assessed by multiple metrics. KLF10 occupied GC-rich sequences in the promoter region of the EMT-promoting transcription factor SLUG/SNAI2, repressing its transcription by recruiting HDAC1 and licensing the removal of activating histone acetylation marks. In clinical specimens of lung adenocarcinoma, low KLF10 expression associated with decreased patient survival, consistent with a pivotal role for KLF10 in distinguishing the antiproliferative versus prometastatic functions of TGF?. Our results establish that KLF10 functions to suppress TGF?-induced EMT, establishing a molecular basis for the dichotomy of TGF? function during tumor progression. Cancer Res; 77(9); 2387-400. ©2017 AACR. |*Feedback, Physiological [MESH] |A549 Cells [MESH] |Adenocarcinoma of Lung [MESH] |Adenocarcinoma/*genetics/pathology [MESH] |Animals [MESH] |Early Growth Response Transcription Factors/*genetics [MESH] |Epithelial-Mesenchymal Transition/*genetics [MESH] |Humans [MESH] |Kruppel-Like Transcription Factors/*genetics [MESH] |Lung Neoplasms/*genetics/pathology [MESH] |Mice, Knockout [MESH] |Patients [MESH] |Promoter Regions, Genetic [MESH] |Signal Transduction [MESH] |Snail Family Transcription Factors/genetics [MESH]Krüppel-like Transcription Factor KLF10 Suppresses TGF?-Induced Epit(epmc).pdf DeepDyve Pubget Overpricing