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2017 ; 18
(1
): 171
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
A retrospective study to assess the evaluation of living related kidney donors
and their outcomes following nephrectomy at Kenyatta National Hospital
#MMPMID28545474
Muturi A
; Kotecha V
; Kanyi S
BMC Nephrol
2017[May]; 18
(1
): 171
PMID28545474
show ga
BACKGROUND: Kidney transplantation is the renal replacement therapy of choice for
end stage renal disease. To ensure safety regular audit of the donation process
is necessary. The aim of this study was to assess the evaluation of potential
living related kidney donors and document their outcomes following nephrectomy.
METHODS: This was a retrospective descriptive study involving all living related
kidney donors seen at Kenyatta National Hospital (KNH) renal unit from 2010 to
2014. Upon approval by KNH/ERC, the records of all kidney donors were retrieved.
Demographic characteristics, number of potential and actual donors, their
clinical, laboratory and radiological data as well as documented complications
and deaths were recorded. SPSS version 17(Chicago, Ilinois) was used for data
entry and analysis. Chi square test and Mann Whitney U test were used as tests of
association for categorical and continuous data respectively, with P value set at
<0.05. RESULTS: Median age of the donors was 34 years (IQR 31-39). First-degree
relatives were majority(84.5%). Renal function assessment was done using mean
glomerular filtration rate (GFR) from the radionuclide scan (DTPA) and serum
creatinine levels. The donors had a mean GFR of 99.2 ± SD 6.6. All the
haematological and biochemical tests were within normal. Majority(42.9%) were HLA
compatible, but data on HLA typing was missing for 22% of the patients records.
On CT angiogram, single renal artery and single renal vein were found in 94 and
88% respectively. Immediate complications included excessive bleeding(2%) and
breach of other cavities (4%). Paralytic ileus (32%) and atelectasis (27%) were
the most common early postoperative complications. There was no mortality.
CONCLUSION: Our study reports no fatality but significant post-operative
complications. These are significant findings that may be used to review and
improve care and to educate potential kidney donors on the safety of this
procedure in our centre, in a bid to widen the pool of potential living kidney
donors.
|Adult
[MESH]
|Age Distribution
[MESH]
|Directed Tissue Donation/*statistics & numerical data
[MESH]
|Female
[MESH]
|Humans
[MESH]
|Kenya/epidemiology
[MESH]
|Kidney Transplantation/*mortality/statistics & numerical data
[MESH]
|Living Donors/*statistics & numerical data
[MESH]
|Male
[MESH]
|Nephrectomy/*mortality/statistics & numerical data
[MESH]