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Deprecated: Implicit conversion from float 284.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Diabetol+Metab+Syndr 2017 ; 9 (ä): ä Nephropedia Template TP
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Soluble plasma proteins ST2 and CD163 as early biomarkers of nephropathy in Swedish patients with diabetes, 15?34 years of age: a prospective cohort study #MMPMID28559931
Samuelsson M; Dereke J; Svensson MK; Landin-Olsson M; Hillman M
Diabetol Metab Syndr 2017[]; 9 (ä): ä PMID28559931show ga
Background: The aim of this study was to investigate plasma levels of sST2 and sCD163 to determine whether they at an early stage could predict development of diabetic nephropathy and/or diabetic retinopathy in patients at clinical onset. Methods: Patients diagnosed with diabetes mellitus at age 15?34 years between 1987 and 1988 (n = 220) were included. Data such as BMI, smoking, HbA1c and islet cell antibodies were collected at time of diagnosis. Within the 10 year follow-up period, 112 patients (51%) developed following diabetes related complications; retinopathy (n = 91), nephropathy (n = 12) or both (n = 9). Plasma concentrations of sST2 and sCD163 were measured at time of diagnosis and levels compared between different complication groups. Results: Plasma levels of sST2 were significantly higher in patients who later developed nephropathy (n = 21; 1012 [773?1493] pg/ml) compared to those who did not (n = 199; 723 [449?1084] pg/ml; p = 0.006). A tendency for higher plasma levels of sCD163 was observed but not statistically significant (p = 0.058). Conclusions: sST2 and sCD163 show promise as potential biomarkers for the development of nephropathy already at clinical onset. sST2 and/or sCD163 could possibly be part of a biomarker panel aimed to find patients at high risk of developing nephropathy. Both markers need to be investigated in a larger prospective study.