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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Diabetol+Metab+Syndr
2017 ; 9
(ä): 41
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Soluble plasma proteins ST2 and CD163 as early biomarkers of nephropathy in
Swedish patients with diabetes, 15-34 years of age: a prospective cohort study
#MMPMID28559931
Samuelsson M
; Dereke J
; Svensson MK
; Landin-Olsson M
; Hillman M
Diabetol Metab Syndr
2017[]; 9
(ä): 41
PMID28559931
show ga
BACKGROUND: The aim of this study was to investigate plasma levels of sST2 and
sCD163 to determine whether they at an early stage could predict development of
diabetic nephropathy and/or diabetic retinopathy in patients at clinical onset.
METHODS: Patients diagnosed with diabetes mellitus at age 15-34 years between
1987 and 1988 (n = 220) were included. Data such as BMI, smoking, HbA1c and islet
cell antibodies were collected at time of diagnosis. Within the 10 year follow-up
period, 112 patients (51%) developed following diabetes related complications;
retinopathy (n = 91), nephropathy (n = 12) or both (n = 9). Plasma concentrations
of sST2 and sCD163 were measured at time of diagnosis and levels compared between
different complication groups. RESULTS: Plasma levels of sST2 were significantly
higher in patients who later developed nephropathy (n = 21; 1012 [773-1493]
pg/ml) compared to those who did not (n = 199; 723 [449-1084] pg/ml; p = 0.006).
A tendency for higher plasma levels of sCD163 was observed but not statistically
significant (p = 0.058). CONCLUSIONS: sST2 and sCD163 show promise as potential
biomarkers for the development of nephropathy already at clinical onset. sST2
and/or sCD163 could possibly be part of a biomarker panel aimed to find patients
at high risk of developing nephropathy. Both markers need to be investigated in a
larger prospective study.