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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Occup+Med+Toxicol
2017 ; 12
(ä): 12
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Prevalence of latent tuberculosis infection among foreign students in Lübeck,
Germany tested with QuantiFERON-TB Gold In-Tube and QuantiFERON-TB Gold Plus
#MMPMID28559919
Gallegos Morales EN
; Knierer J
; Schablon A
; Nienhaus A
; Kersten JF
J Occup Med Toxicol
2017[]; 12
(ä): 12
PMID28559919
show ga
BACKGROUND: The tuberculosis (TB) incidence rate in foreign-born individuals has
been increasing in Germany in recent years. Foreign students may be an important
source of latent tuberculosis infection (LTBI) in low-incidence countries. In
Germany, there are no guidelines for LTBI screening of foreign students. The aim
of the study was to estimate LTBI prevalence and evaluate associated risk factors
among foreign students in Germany. The second purpose of our study was to compare
the results of the new generation of QuantiFERON-TB Gold Plus (QFT-Plus) to those
of its predecessor QuantiFERON-TB Gold In-Tube (QFT-GIT). METHODS: This
cross-sectional study was conducted between February 2016 and March 2016. Foreign
students and young professionals attending the university and higher education
institutes in Lübeck, Germany were tested with QFT-Plus and QFT-GIT. Participants
filled out a questionnaire for the purpose of LTBI risk assessment and analysis.
Variables associated with a positive test result were analyzed using logistic
regression. RESULTS: One hundred thirty four students participated in the study.
The overall prevalence as regards positive results from both tests, QFT-Plus and
QFT-GIT, was 9.7%, and the prevalence of positive QFT-Plus results was 8.2%. The
main independent variables associated with a positive QFT-Plus result were a)
being born in a high-incidence country (OR = 6.7, 95% CI: 1.3-34.3) and b)
previous contact with a person with active TB (OR = 4.5, 95% CI: 1.1-18.3).
Higher age (OR = 2.8, 95% CI: 0.7-11.3) and male gender (OR = 1.6, 95% CI:
0.4-6.7) showed a tendency toward positive QFT-Plus results but this was not
statistically significant. Agreement between QFT-Plus and QFT-GIT results was
? = 0.85, p < 0.001. CONCLUSIONS: The LTBI prevalence among foreign students was
about 10%. We recommend implementing a policy whereby all foreign students are
screened by means of a questionnaire about LTBI risk factors, so that only
students with present risk factors are tested for LTBI. The agreement between the
new QFT-Plus and the QFT-GIT (? = 0.85) was good. QFT-Plus might be used in the
same format as its predecessor.