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2017 ; 18
(1
): 173
Nephropedia Template TP
gab.com Text
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Twit Text #
English Wikipedia
Diagnostic performance of serum blood urea nitrogen to creatinine ratio for
distinguishing prerenal from intrinsic acute kidney injury in the emergency
department
#MMPMID28545421
Manoeuvrier G
; Bach-Ngohou K
; Batard E
; Masson D
; Trewick D
BMC Nephrol
2017[May]; 18
(1
): 173
PMID28545421
show ga
BACKGROUND: The blood urea nitrogen to creatinine ratio (BCR) has been used since
the early 1940s to help clinicians differentiate between prerenal acute kidney
injury (PR AKI) and intrinsic AKI (I AKI). This ratio is simple to use and often
put forward as a reliable diagnostic tool even though little scientific evidence
supports this. The aim of this study was to determine whether BCR is a reliable
tool for distinguishing PR AKI from I AKI. METHODS: We conducted a retrospective
observational study over a 13 months period, in the Emergency Department (ED) of
Nantes University Hospital. Eligible for inclusion were all adult patients
consecutively admitted to the ED with a creatinine >133 ?mol/L (1.5 mg/dL).
RESULTS: Sixty thousand one hundred sixty patients were consecutively admitted to
the ED. 2756 patients had plasma creatinine levels in excess of 133 ?mol/L, 1653
were excluded, leaving 1103 patients for definitive inclusion. Mean age was
75.7 ± 14.8 years old, 498 (45%) patients had PR AKI and 605 (55%) I AKI. BCR was
90.55 ± 39.32 and 91.29 ± 39.79 in PR AKI and I AKI groups respectively. There
was no statistical difference between mean BCR of the PR AKI and I AKI groups,
p = 0.758. The area under the ROC curve was 0.5 indicating that BCR had no
capacity to discriminate between PR AKI and I AKI. CONCLUSIONS: Our study is the
largest to investigate the diagnostic performance of BCR. BCR is not a reliable
parameter for distinguishing prerenal AKI from intrinsic AKI.