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10.1038/s41598-017-02653-9 http://scihub22266oqcxt.onion/10.1038/s41598-017-02653-9 C5445095!5445095 !28546567     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28546567 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2017 ; 7 (1 ): 2421 Nephropedia Template TP {{tp|p=28546567 |t=2017. Thymic homing of activated CD4(+) T cells induces degeneration of the thymic epithelium through excessive RANK signaling |pdf=|usr=}}{{28546567 }} gab.com Text Thymic homing of activated CD4(+) T cells induces degeneration of the thymic epithelium through excessive RANK signaling JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28546567 #FOAvip Activated T cells have been shown to be able to recirculate into the thymus from the periphery. The present study was aimed to elucidate the functional consequences of thymic homing of activated T cells upon developing thymocytes and thymic epithelial cells (TEC). In the presence of activated T cells, especially CD4(+) T cells, T cell development was found to be inhibited in thymic organ cultures with markedly reduced cellularity. Thymic transplantation demonstrated that the inhibitory effect was most likely due to a defective microenvironment. As the major component of the thymic stroma, the TEC compartment was severely disturbed after prolonged exposure to the activated T cells. In addition to reduced cell proliferation, TEC differentiation was heavily skewed to the mTEC lineage. Furthermore, we demonstrated that RANKL highly expressed by activated CD4(+) T cells was primarily responsible for the detrimental effects. Presumably, excessive RANK signaling drove overproduction of mTECs and possibly exhaustion of epithelial progenitors, thereby facilitating the deterioration of the epithelial structures. These findings not only reveal a novel activity of activated T cells re-entering the thymus, but also provide a new perspective for understanding the mechanism underlying thymic involution. Twit Text FOAVip Thymic homing of activated CD4(+) T cells induces degeneration of the thymic epithelium through excessive RANK signaling ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28546567 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28546567 #FOAvip English Wikipedia <ref>{{Cite pmid|28546567 }}</ref> Thymic homing of activated CD4(+) T cells induces degeneration of the thymic epithelium through excessive RANK signaling #MMPMID28546567 Yin C ; Pei XY ; Shen H ; Gao YN ; Sun XY ; Wang W ; Ge Q ; Zhang Y Sci Rep 2017[May]; 7 (1 ): 2421 PMID28546567 show ga Activated T cells have been shown to be able to recirculate into the thymus from the periphery. The present study was aimed to elucidate the functional consequences of thymic homing of activated T cells upon developing thymocytes and thymic epithelial cells (TEC). In the presence of activated T cells, especially CD4(+) T cells, T cell development was found to be inhibited in thymic organ cultures with markedly reduced cellularity. Thymic transplantation demonstrated that the inhibitory effect was most likely due to a defective microenvironment. As the major component of the thymic stroma, the TEC compartment was severely disturbed after prolonged exposure to the activated T cells. In addition to reduced cell proliferation, TEC differentiation was heavily skewed to the mTEC lineage. Furthermore, we demonstrated that RANKL highly expressed by activated CD4(+) T cells was primarily responsible for the detrimental effects. Presumably, excessive RANK signaling drove overproduction of mTECs and possibly exhaustion of epithelial progenitors, thereby facilitating the deterioration of the epithelial structures. These findings not only reveal a novel activity of activated T cells re-entering the thymus, but also provide a new perspective for understanding the mechanism underlying thymic involution. |*Signal Transduction [MESH] |Animals [MESH] |CD4-Positive T-Lymphocytes/*immunology/*metabolism [MESH] |Cell Movement/immunology [MESH] |Cells, Cultured [MESH] |Epithelial Cells/metabolism [MESH] |Flow Cytometry [MESH] |Lymphocyte Activation/*immunology [MESH] |Lymphopoiesis/immunology [MESH] |Mice [MESH] |Receptor Activator of Nuclear Factor-kappa B/*metabolism [MESH] |Thymocytes/*immunology/*metabolism [MESH]Thymic homing of activated CD4(+) T cells induces degeneration of the (epmc).pdf DeepDyve Pubget Overpricing