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2017 ; 8
(18
): 30595-30605
Nephropedia Template TP
gab.com Text
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English Wikipedia
Therapeutic role of glutamine in management of radiation enteritis: a
meta-analysis of 13 randomized controlled trials
#MMPMID28427169
Cao DD
; Xu HL
; Xu M
; Qian XY
; Yin ZC
; Ge W
Oncotarget
2017[May]; 8
(18
): 30595-30605
PMID28427169
show ga
OBJECTIVE: To systematically evaluate the clinical efficacy of glutamine in
treating radiation enteritis in cancer patients treated with radiotherapy.
METHODS: Electronic databases including Pubmed, Embase, the Cochrane library, and
CNKI were systematically searched, until April 2016. Randomized controlled trials
(RCT) of glutamine in the treatment of radiation enteritis in cancer patients
were searched, and RevMan 5.3 software was used for Meta-analysis. RESULTS: A
total of 13 RCTs were included, involving 979 patients. The results of
meta-analysis showed that the total efficacy of glutamine was higher for patients
with radiation enteritis compared with that in control group, however, there was
no statistically significant difference(OR = 3.07, 95%CI: 0.79-11.96; P > 0.05).
The combined ORs for all 5 grades(from grade 0 to grade 4) of radiation enteritis
in patients receiving glutamine were 2.06, 1.35, 0.55, 0.62 and 0.59,
respectively(P > 0.05 for all). Glutamine also failed to significantly improve
the symptoms of radiation enteritis in terms of tenesmus, abdominal cramping and
blood in bowel movement(P > 0.05). CONCLUSIONS: Implementation of glutamine fails
to improve the severity and symptoms in patients with radiation enteritis.