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10.18632/oncotarget.15426 http://scihub22266oqcxt.onion/10.18632/oncotarget.15426 C5444761!5444761 !28430622     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28430622 &cmd=llinks): Failed to open stream: HTTP request failed! 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Serious adverse events of cell therapy for respiratory diseases: a systematic review and meta-analysis |pdf=|usr=}}{{28430622 }} gab.com Text Serious adverse events of cell therapy for respiratory diseases: a systematic review and meta-analysis JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28430622 #FOAvip BACKGROUND: Cell therapy holds the most promising for acute and chronic deleterious respiratory diseases. However, the safety and tolerance for lung disorders are controversy. METHODS: We undertook a systematic review and meta-analyses of all 23 clinical studies of cell therapy. The outcomes were odds ratio (OR), risk difference (RD), Peto OR, relative risk, and mean difference of serious adverse events. RESULTS: 342 systemic infusions and 57 bronchial instillations (204 recipients) of cells were analyzed for acute respiratory distress syndrome (ARDS), bronchopulmonary dysplasia, pulmonary arterial hypertension, silicosis, sarcoidosis, extensively drug-resistant tuberculosis, chronic obstructive pulmonary diseases (COPD), and idiopathic pulmonary fibrosis. The frequency of death in adults from any causes was 71 and 177 per 1,000 for cell therapy and controls, respectively, with an OR of 0.31 (95% CI: 0.03, 3.76) and RD of -0.22 (95% CI: -0.53, 0.09). No significant difference was found for ARDS and COPD. The frequency of deaths and non-fatal serious adverse events of 17 open studies were similar to those of randomized controlled trials. Moreover, serious adverse events of allogenic cells were greater than autologous preparations, as shown by frequency, OR and RD. CONCLUSIONS: We conclude that either infusion or instillation of mesenchymal stem stromal or progenitor cells are well tolerated without serious adverse events causally related to cell treatment. Cell therapy has not been associated with significant changes in spirometry, immune function, cardiovascular activity, and the quality of life. Twit Text FOAVip Serious adverse events of cell therapy for respiratory diseases: a systematic review and meta-analysis ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28430622 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28430622 #FOAvip English Wikipedia <ref>{{Cite pmid|28430622 }}</ref> Serious adverse events of cell therapy for respiratory diseases: a systematic review and meta-analysis #MMPMID28430622 Zhao R ; Su Z ; Wu J ; Ji HL Oncotarget 2017[May]; 8 (18 ): 30511-30523 PMID28430622 show ga BACKGROUND: Cell therapy holds the most promising for acute and chronic deleterious respiratory diseases. However, the safety and tolerance for lung disorders are controversy. METHODS: We undertook a systematic review and meta-analyses of all 23 clinical studies of cell therapy. The outcomes were odds ratio (OR), risk difference (RD), Peto OR, relative risk, and mean difference of serious adverse events. RESULTS: 342 systemic infusions and 57 bronchial instillations (204 recipients) of cells were analyzed for acute respiratory distress syndrome (ARDS), bronchopulmonary dysplasia, pulmonary arterial hypertension, silicosis, sarcoidosis, extensively drug-resistant tuberculosis, chronic obstructive pulmonary diseases (COPD), and idiopathic pulmonary fibrosis. The frequency of death in adults from any causes was 71 and 177 per 1,000 for cell therapy and controls, respectively, with an OR of 0.31 (95% CI: 0.03, 3.76) and RD of -0.22 (95% CI: -0.53, 0.09). No significant difference was found for ARDS and COPD. The frequency of deaths and non-fatal serious adverse events of 17 open studies were similar to those of randomized controlled trials. Moreover, serious adverse events of allogenic cells were greater than autologous preparations, as shown by frequency, OR and RD. CONCLUSIONS: We conclude that either infusion or instillation of mesenchymal stem stromal or progenitor cells are well tolerated without serious adverse events causally related to cell treatment. Cell therapy has not been associated with significant changes in spirometry, immune function, cardiovascular activity, and the quality of life. |Cell- and Tissue-Based Therapy/*adverse effects/methods [MESH] |Clinical Trials as Topic [MESH] |Humans [MESH] |Mesenchymal Stem Cells [MESH] |Odds Ratio [MESH] |Respiratory Tract Diseases/*complications/mortality/*therapy [MESH]Serious adverse events of cell therapy for respiratory diseases: a sys(epmc).pdf DeepDyve Pubget Overpricing