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10.1016/j.cmet.2017.03.003 http://scihub22266oqcxt.onion/10.1016/j.cmet.2017.03.003 C5444661!5444661!28380376     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Metab 2017 ; 25 (4): 838-855.e15 Nephropedia Template TP {{tp|p=28380376|t=2017. SIRT4 is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion |pdf=|usr=}}{{28380376}} gab.com Text SIRT4 is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion JO: Cell Metab http://www.kidney.de/pget.php?&tw=1&pmid=28380376 #FOAvip Sirtuins are NAD+-dependent protein deacylases that regulate several aspects of metabolism and aging. In contrast to the other mammalian sirtuins, the primary enzymatic activity of mitochondrial sirtuin 4 (SIRT4) and its overall role in metabolic control has remained enigmatic. Using a combination of phylogenetics, structural biology, and enzymology, we show that SIRT4 removes three acyl moieties from lysine residues ? methylglutaryl(MG)-, hydroxymethylglutaryl(HMG)-, and 3-methylglutaconyl(MGc)-lysine. The metabolites leading to these post-translational modifications are intermediates in leucine oxidation, and we show a primary role for SIRT4 in controlling this pathway in mice. Furthermore, we find that dysregulated leucine metabolism in SIRT4KO mice leads to elevated basal and stimulated insulin secretion, which progressively develops into glucose intolerance and insulin resistance. These findings identify a robust enzymatic activity for SIRT4, uncover a mechanism controlling branched-chain amino acid flux, and position SIRT4 as a crucial player maintaining insulin secretion and glucose homeostasis during aging. Twit Text FOAVip SIRT4 is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion ????Cell Metab http://www.kidney.de/pget.php?&tw=1&pmid=28380376 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28380376 #FOAvip English Wikipedia <ref>{{Cite pmid|28380376}}</ref> SIRT4 is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion #MMPMID28380376 Anderson KA; Huynh FK; Fisher-Wellman K; Stuart JD; Peterson BS; Douros JD; Wagner GR; Thompson JW; Madsen AS; Green MF; Sivley RM; Ilkayeva OR; Stevens RD; Backos DS; Capra JA; Olsen CA; Campbell JE; Muoio DM; Grimsrud PA; Hirschey MD Cell Metab 2017[Apr]; 25 (4): 838-855.e15 PMID28380376show ga Sirtuins are NAD+-dependent protein deacylases that regulate several aspects of metabolism and aging. In contrast to the other mammalian sirtuins, the primary enzymatic activity of mitochondrial sirtuin 4 (SIRT4) and its overall role in metabolic control has remained enigmatic. Using a combination of phylogenetics, structural biology, and enzymology, we show that SIRT4 removes three acyl moieties from lysine residues ? methylglutaryl(MG)-, hydroxymethylglutaryl(HMG)-, and 3-methylglutaconyl(MGc)-lysine. The metabolites leading to these post-translational modifications are intermediates in leucine oxidation, and we show a primary role for SIRT4 in controlling this pathway in mice. Furthermore, we find that dysregulated leucine metabolism in SIRT4KO mice leads to elevated basal and stimulated insulin secretion, which progressively develops into glucose intolerance and insulin resistance. These findings identify a robust enzymatic activity for SIRT4, uncover a mechanism controlling branched-chain amino acid flux, and position SIRT4 as a crucial player maintaining insulin secretion and glucose homeostasis during aging. äSIRT4 is a Lysine Deacylase that Controls Leucine Metabolism and Insul(epmc).pdf DeepDyve Pubget Overpricing