Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1371/journal.pone.0177862 http://scihub22266oqcxt.onion/10.1371/journal.pone.0177862 C5443501!5443501 !28542422     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28542422 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28542422 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       PLoS+One 2017 ; 12 (5 ): e0177862 Nephropedia Template TP {{tp|p=28542422 |t=2017. Angelica Dahurica ethanolic extract improves impaired wound healing by activating angiogenesis in diabetes |pdf=|usr=}}{{28542422 }} gab.com Text Angelica Dahurica ethanolic extract improves impaired wound healing by activating angiogenesis in diabetes JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=28542422 #FOAvip Abnormal angiogenesis plays an important role in impaired wound healing and development of chronic wounds in diabetes mellitus. Angelica dahurica radix is a common traditional Chinese medicine with wide spectrum medicinal effects. In this study, we analyzed the potential roles of Angelica dahurica ethanolic extract (ADEE) in correcting impaired angiogenesis and delayed wound healing in diabetes by using streptozotocin-induced diabetic rats. ADEE treatment accelerated diabetic wound healing through inducing angiogenesis and granulation tissue formation. The angiogenic property of ADEE was subsequently verified ex vivo using aortic ring assays. Furthermore, we investigated the in vitro angiogenic activity of ADEE and its underlying mechanisms using human umbilical vein endothelial cells. ADEE treatment induced HUVECs proliferation, migration, and tube formation, which are typical phenomena of angiogenesis, in dose-dependent manners. These effects were associated with activation of angiogenic signal modulators, including extracellular signal-regulated kinase 1/2 (ERK1/2), Akt, endothelial nitric oxide synthase (eNOS) as well as increased NO production, and independent of affecting VEGF expression. ADEE-induced angiogenic events were inhibited by the MEK inhibitor PD98059, the PI3K inhibitor Wortmannin, and the eNOS inhibitor L-NAME. Our findings highlight an angiogenic role of ADEE and its ability to protect against impaired wound healing, which may be developed as a promising therapy for impaired angiogenesis and delayed wound healing in diabetes. Twit Text FOAVip Angelica Dahurica ethanolic extract improves impaired wound healing by activating angiogenesis in diabetes ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=28542422 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28542422 #FOAvip English Wikipedia <ref>{{Cite pmid|28542422 }}</ref> Angelica Dahurica ethanolic extract improves impaired wound healing by activating angiogenesis in diabetes #MMPMID28542422 Zhang XN ; Ma ZJ ; Wang Y ; Sun B ; Guo X ; Pan CQ ; Chen LM PLoS One 2017[]; 12 (5 ): e0177862 PMID28542422 show ga Abnormal angiogenesis plays an important role in impaired wound healing and development of chronic wounds in diabetes mellitus. Angelica dahurica radix is a common traditional Chinese medicine with wide spectrum medicinal effects. In this study, we analyzed the potential roles of Angelica dahurica ethanolic extract (ADEE) in correcting impaired angiogenesis and delayed wound healing in diabetes by using streptozotocin-induced diabetic rats. ADEE treatment accelerated diabetic wound healing through inducing angiogenesis and granulation tissue formation. The angiogenic property of ADEE was subsequently verified ex vivo using aortic ring assays. Furthermore, we investigated the in vitro angiogenic activity of ADEE and its underlying mechanisms using human umbilical vein endothelial cells. ADEE treatment induced HUVECs proliferation, migration, and tube formation, which are typical phenomena of angiogenesis, in dose-dependent manners. These effects were associated with activation of angiogenic signal modulators, including extracellular signal-regulated kinase 1/2 (ERK1/2), Akt, endothelial nitric oxide synthase (eNOS) as well as increased NO production, and independent of affecting VEGF expression. ADEE-induced angiogenic events were inhibited by the MEK inhibitor PD98059, the PI3K inhibitor Wortmannin, and the eNOS inhibitor L-NAME. Our findings highlight an angiogenic role of ADEE and its ability to protect against impaired wound healing, which may be developed as a promising therapy for impaired angiogenesis and delayed wound healing in diabetes. |Androstadienes/pharmacology [MESH] |Angelica/*metabolism [MESH] |Animals [MESH] |Aorta/metabolism [MESH] |Cell Line [MESH] |Cell Movement/drug effects [MESH] |Cell Proliferation/drug effects [MESH] |Diabetes Mellitus, Experimental/*pathology [MESH] |Enzyme Activation/drug effects [MESH] |Extracellular Signal-Regulated MAP Kinases/antagonists & inhibitors/metabolism [MESH] |Flavonoids/pharmacology [MESH] |Human Umbilical Vein Endothelial Cells [MESH] |Humans [MESH] |Medicine, Chinese Traditional [MESH] |NG-Nitroarginine Methyl Ester/pharmacology [MESH] |Neovascularization, Physiologic/*drug effects [MESH] |Nitric Oxide Synthase Type III/antagonists & inhibitors/metabolism [MESH] |Nitric Oxide/biosynthesis [MESH] |Plant Extracts/*therapeutic use [MESH] |Proto-Oncogene Proteins c-akt/antagonists & inhibitors/metabolism [MESH] |Rats [MESH] |Rats, Sprague-Dawley [MESH] |Signal Transduction/drug effects [MESH] |Streptozocin [MESH] |Wortmannin [MESH]Angelica Dahurica ethanolic extract improves impaired wound healing by(epmc).pdf DeepDyve Pubget Overpricing