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10.3892/etm.2017.4261 http://scihub22266oqcxt.onion/10.3892/etm.2017.4261 C5443285!5443285!28565830     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 282.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Exp+Ther+Med 2017 ; 13 (5): 2217-24 Nephropedia Template TP {{tp|p=28565830|t=2017. Correlation between PKB/Akt, GSK-3? expression and tubular epithelial-mesenchymal transition in renal allografts with chronic active antibody-mediated rejection |pdf=|usr=}}{{28565830}} gab.com Text Correlation between PKB/Akt, GSK-3 expression and tubular epithelial-mesenchymal transition in renal allografts with chronic active antibody-mediated rejection JO: Exp Ther Med http://www.kidney.de/pget.php?&tw=1&pmid=28565830 #FOAvip Chronic antibody-mediated rejection (ABMR) is a major cause of the transplant renal interstitial fibrosis and transplanted kidney epithelial cell transdifferentiation is one of the main mechanisms. The transforming growth factor (TGF)-?1/integrin-linked kinase (ILK) signaling pathway has a significant role in the epithelial-mesenchymal transition (EMT) of renal tubular epithelial cells; however, the molecular mechanisms of this process have remained elusive. The present study confirmed that Akt and glycogen synthase kinase (GSK)-3?, as TGF-?1 downstream signaling factors, are involved in fibrotic processes caused by kidney disease, which, however, has been rarely reported in the kidney transplant field. Based on the Banff 2009 standard, transplanted kidney specimens were classified according to the fibrosis level. The results showed that with the reduction of the interstitial fibrosis level, E-cadherin expression was gradually reduced, while ?-smooth muscle actin expression progressively increased. The expression of Akt and GSK-3? in normal human kidney tissue was not obvious but showed a marked increase with the aggravation of the interstitial fibrosis level, which confirmed the occurrence of EMT during the fibrosis process, and that phosphorylated (p)-Akt and GSK-3? have an important role in the EMT process in the transplanted kidney. A correlation analysis of p-Akt, GSK-3?, TGF-?1 and ILK suggested that overexpression of p-Akt and GSK-3? may induce and mediate the transdifferentiation of renal tubular epithelial cells to myofibroblasts and that this proceeds via TGF?1/ILK signaling pathways. Twit Text FOAVip Correlation between PKB/Akt, GSK-3 expression and tubular epithelial-mesenchymal transition in renal allografts with chronic active antibody-mediated rejection ????Exp Ther Med http://www.kidney.de/pget.php?&tw=1&pmid=28565830 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28565830 #FOAvip English Wikipedia <ref>{{Cite pmid|28565830}}</ref> Correlation between PKB/Akt, GSK-3? expression and tubular epithelial-mesenchymal transition in renal allografts with chronic active antibody-mediated rejection #MMPMID28565830 Yan Q; Luo H; Wang B; Sui W; Zou G; Chen H; Zou H Exp Ther Med 2017[May]; 13 (5): 2217-24 PMID28565830show ga Chronic antibody-mediated rejection (ABMR) is a major cause of the transplant renal interstitial fibrosis and transplanted kidney epithelial cell transdifferentiation is one of the main mechanisms. The transforming growth factor (TGF)-?1/integrin-linked kinase (ILK) signaling pathway has a significant role in the epithelial-mesenchymal transition (EMT) of renal tubular epithelial cells; however, the molecular mechanisms of this process have remained elusive. The present study confirmed that Akt and glycogen synthase kinase (GSK)-3?, as TGF-?1 downstream signaling factors, are involved in fibrotic processes caused by kidney disease, which, however, has been rarely reported in the kidney transplant field. Based on the Banff 2009 standard, transplanted kidney specimens were classified according to the fibrosis level. The results showed that with the reduction of the interstitial fibrosis level, E-cadherin expression was gradually reduced, while ?-smooth muscle actin expression progressively increased. The expression of Akt and GSK-3? in normal human kidney tissue was not obvious but showed a marked increase with the aggravation of the interstitial fibrosis level, which confirmed the occurrence of EMT during the fibrosis process, and that phosphorylated (p)-Akt and GSK-3? have an important role in the EMT process in the transplanted kidney. A correlation analysis of p-Akt, GSK-3?, TGF-?1 and ILK suggested that overexpression of p-Akt and GSK-3? may induce and mediate the transdifferentiation of renal tubular epithelial cells to myofibroblasts and that this proceeds via TGF?1/ILK signaling pathways. äCorrelation between PKB/Akt, GSK-3? expression and tubular epithelial-(epmc).pdf DeepDyve Pubget Overpricing