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10.3389/fneur.2017.00206 http://scihub22266oqcxt.onion/10.3389/fneur.2017.00206 C5443142!5443142!28596752     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Neurol 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=28596752|t=2017. The Retina in Multiple System Atrophy: Systematic Review and Meta-Analysis |pdf=|usr=}}{{28596752}} gab.com Text The Retina in Multiple System Atrophy: Systematic Review and Meta-Analysis JO: Front Neurol http://www.kidney.de/pget.php?&tw=1&pmid=28596752 #FOAvip Background: Multiple system atrophy (MSA) is a rare, adult-onset, rapidly progressive fatal synucleinopathy that primarily affects oligodendroglial cells in the brain. Patients with MSA only rarely have visual complaints, but recent studies of the retina using optical coherence tomography (OCT) showed atrophy of the peripapillary retinal nerve fiber layer (RNFL) and to a lesser extent the macular ganglion cell layer (GCL) complex. Methods: We performed a literature review and meta-analysis according to the preferred reporting items for systematic reviews and meta-analyses guidelines for studies published before January 2017, identified through PubMed and Google Scholar databases, which reported OCT-related outcomes in patients with MSA and controls. A random-effects model was constructed. Results: The meta-analysis search strategy yielded 15 articles of which 7 met the inclusion criteria. The pooled difference in the average thickness of the RNFL was ?5.48??m (95% CI, ?6.23 to ?4.73; p?<?0.0001), indicating significant thinning in patients with MSA. The pooled results showed significant thinning in all the specific RNFL quadrants, except in the temporal RNFL quadrant, where the thickness in MSA and controls was similar [pooled difference of 1.11?µm (95% CI, ?4.03 to 6.26; p?=?0.67)]. This pattern of retinal damage suggests that MSA patients have preferential loss of retinal ganglion cells projecting to the magnocellular pathway (M-cells), which are mainly located in the peripheral retina and are not essential for visual acuity. Visual acuity, on the other hand, relies mostly on macular ganglion cells projecting to the parvocellular pathway (P-cells) through the temporal portion of the RNFL, which are relatively spared in MSA patients. Conclusion: The retinal damage in patients with MSA differs from that observed in patients with Parkinson disease (PD). Patients with MSA have more relative preservation of temporal sector of the RNFL and less severe atrophy of the macular GCL complex. We hypothesize that in patients with MSA there is predominant damage of large myelinated optic nerve axons like those originating from the M-cells. These large axons may require higher support from oligodendrocytes. Conversely, in patients with PD, P-cells might be more affected. Twit Text FOAVip The Retina in Multiple System Atrophy: Systematic Review and Meta-Analysis ????Front Neurol http://www.kidney.de/pget.php?&tw=1&pmid=28596752 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28596752 #FOAvip English Wikipedia <ref>{{Cite pmid|28596752}}</ref> The Retina in Multiple System Atrophy: Systematic Review and Meta-Analysis #MMPMID28596752 Mendoza-Santiesteban CE; Gabilondo I; Palma JA; Norcliffe-Kaufmann L; Kaufmann H Front Neurol 2017[]; 8 (ä): ä PMID28596752show ga Background: Multiple system atrophy (MSA) is a rare, adult-onset, rapidly progressive fatal synucleinopathy that primarily affects oligodendroglial cells in the brain. Patients with MSA only rarely have visual complaints, but recent studies of the retina using optical coherence tomography (OCT) showed atrophy of the peripapillary retinal nerve fiber layer (RNFL) and to a lesser extent the macular ganglion cell layer (GCL) complex. Methods: We performed a literature review and meta-analysis according to the preferred reporting items for systematic reviews and meta-analyses guidelines for studies published before January 2017, identified through PubMed and Google Scholar databases, which reported OCT-related outcomes in patients with MSA and controls. A random-effects model was constructed. Results: The meta-analysis search strategy yielded 15 articles of which 7 met the inclusion criteria. The pooled difference in the average thickness of the RNFL was ?5.48??m (95% CI, ?6.23 to ?4.73; p? äThe Retina in Multiple System Atrophy: Systematic Review and Meta-Anal(epmc).pdf DeepDyve Pubget Overpricing