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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Otolaryngol+Head+Neck+Surg
2017 ; 46
(1
): 41
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gab.com Text
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Current insights in noise-induced hearing loss: a literature review of the
underlying mechanism, pathophysiology, asymmetry, and management options
#MMPMID28535812
Le TN
; Straatman LV
; Lea J
; Westerberg B
J Otolaryngol Head Neck Surg
2017[May]; 46
(1
): 41
PMID28535812
show ga
BACKGROUND: Noise-induced hearing loss is one of the most common forms of
sensorineural hearing loss, is a major health problem, is largely preventable and
is probably more widespread than revealed by conventional pure tone threshold
testing. Noise-induced damage to the cochlea is traditionally considered to be
associated with symmetrical mild to moderate hearing loss with associated
tinnitus; however, there is a significant number of patients with asymmetrical
thresholds and, depending on the exposure, severe to profound hearing loss as
well. MAIN BODY: Recent epidemiology and animal studies have provided further
insight into the pathophysiology, clinical findings, social and economic impacts
of noise-induced hearing loss. Furthermore, it is recently shown that acoustic
trauma is associated with vestibular dysfunction, with associated dizziness that
is not always measurable with current techniques. Deliberation of the prevalence,
treatment and prevention of noise-induced hearing loss is important and timely.
Currently, prevention and protection are the first lines of defence, although
promising protective effects are emerging from multiple different pharmaceutical
agents, such as steroids, antioxidants and neurotrophins. CONCLUSION: This review
provides a comprehensive update on the pathophysiology, investigations,
prevalence of asymmetry, associated symptoms, and current strategies on the
prevention and treatment of noise-induced hearing loss.