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Cancer Stem Cells Therapeutic Target Database: The First Comprehensive Database
for Therapeutic Targets of Cancer Stem Cells
#MMPMID28191780
Hu X
; Cong Y
; Luo HH
; Wu S
; Zhao LE
; Liu Q
; Yang Y
Stem Cells Transl Med
2017[Feb]; 6
(2
): 331-334
PMID28191780
show ga
Cancer stem cells (CSCs) are a subpopulation of tumor cells that have strong
self-renewal capabilities and may contribute to the failure of conventional
cancer therapies. Hence, therapeutics homing in on CSCs represent a novel and
promising approach that may eradicate malignant tumors. However, the lack of
information on validated targets of CSCs has greatly hindered the development of
CSC-directed therapeutics. Herein, we describe the Cancer Stem Cells Therapeutic
Target Database (CSCTT), the first online database to provide a rich
bioinformatics resource for the display, search, and analysis of structure,
function, and related annotation for therapeutic targets of cancer stem cells.
CSCTT contains 135 proteins that are potential targets of CSCs, with validated
experimental evidence manually curated from existing literatures. Proteins are
carefully annotated with a detailed description of protein families, biological
process, related diseases, and experimental evidences. In addition, CSCTT has
compiled 213 documented therapeutic methods for cancer stem cells, including 118
small molecules and 20 biotherapy methods. The CSCTT may serve as a useful
platform for the development of CSC-directed therapeutics against various
malignant tumors. The CSCTT database is freely available to the public at
http://www.csctt.org/. Stem Cells Translational Medicine 2017;6:331-334.
free
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