Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28191766
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28191766
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Stem+Cells+Transl+Med
2017 ; 6
(2
): 539-565
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Concise Review: Mesenchymal Stem Cell Therapy for Pediatric Disease: Perspectives
on Success and Potential Improvements
#MMPMID28191766
Nitkin CR
; Bonfield TL
Stem Cells Transl Med
2017[Feb]; 6
(2
): 539-565
PMID28191766
show ga
Mesenchymal stem cells (MSCs) represent a potentially revolutionary therapy for a
wide variety of pediatric diseases, but the optimal cell-based therapeutics for
such diversity have not yet been specified. The published clinical trials for
pediatric pulmonary, cardiac, orthopedic, endocrine, neurologic, and hematologic
diseases provide evidence that MSCs are indeed efficacious, but the significant
heterogeneity in therapeutic approaches between studies raises new questions. The
purpose of this review is to stimulate new preclinical and clinical trials to
investigate these factors. First, we discuss recent clinical trials for pediatric
diseases studying MSCs obtained from bone marrow, umbilical cord and umbilical
cord blood, placenta, amniotic fluid, and adipose tissue. We then identify
factors, some unique to pediatrics, which must be examined to optimize
therapeutic efficacy, including route of administration, dose, timing of
administration, the role of ex vivo differentiation, cell culture techniques,
donor factors, host factors, and the immunologic implications of allogeneic
therapy. Finally, we discuss some of the practicalities of bringing cell-based
therapy into the clinic, including regulatory and manufacturing considerations.
The aim of this review is to inform future studies seeking to maximize
therapeutic efficacy for each disease and for each patient. Stem Cells
Translational Medicine 2017;6:539-565.