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10.5966/sctm.2015-0411 http://scihub22266oqcxt.onion/10.5966/sctm.2015-0411 C5442798!5442798 !28191756     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28191756 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Stem+Cells+Transl+Med 2017 ; 6 (2 ): 394-404 Nephropedia Template TP {{tp|p=28191756 |t=2017. Aberrant Transforming Growth Factor-? Activation Recruits Mesenchymal Stem Cells During Prostatic Hyperplasia |pdf=|usr=}}{{28191756 }} gab.com Text Aberrant Transforming Growth Factor- Activation Recruits Mesenchymal Stem Cells During Prostatic Hyperplasia JO: Stem Cells Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=28191756 #FOAvip Benign prostatic hyperplasia (BPH) is the overgrowth of prostate tissues with high prevalence in older men. BPH pathogenesis is not completely understood, but it is believed to be a result of de novo overgrowth of prostatic stroma. In this study, we show that aberrant activation of transforming growth factor-? (TGF-?) mobilizes mesenchymal/stromal stem cells (MSCs) in circulating blood, which are recruited for the prostatic stromal hyperplasia. Elevated levels of active TGF-? were observed in both a phenylephrine-induced prostatic hyperplasia mouse model and human BPH tissues. Nestin lineage tracing revealed that 39.6% ± 6.3% of fibroblasts and 73.3% ± 4.2% smooth muscle cells were derived from nestin(+) cells in Nestin-Cre, Rosa26-YFP(flox/+) mice. Nestin(+) MSCs were increased in the prostatic hyperplasia mice. Our parabiosis experiment demonstrate that nestin(+) MSCs were mobilized and recruited to the prostatic stroma of wild-type mice and gave rise to the fibroblasts. Moreover, injection of a TGF-? neutralizing antibody (1D11) inhibits mobilization of MSCs, their recruitment to the prostatic stroma and hyperplasia. Importantly, knockout of T?RII in nestin(+) cell lineage ameliorated stromal hyperplasia. Thus, elevated levels of TGF-?-induced mobilization and recruitment of MSCs to the reactive stroma resulting in overgrowth of prostate tissues in BPH and, thus, inhibition of TGF-? activity could be a potential therapy for BPH. Stem Cells Translational Medicine 2017;6:394-404. Twit Text FOAVip Aberrant Transforming Growth Factor- Activation Recruits Mesenchymal Stem Cells During Prostatic Hyperplasia ????Stem Cells Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=28191756 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28191756 #FOAvip English Wikipedia <ref>{{Cite pmid|28191756 }}</ref> Aberrant Transforming Growth Factor-? Activation Recruits Mesenchymal Stem Cells During Prostatic Hyperplasia #MMPMID28191756 Wang L ; Xie L ; Tintani F ; Xie H ; Li C ; Cui Z ; Wan M ; Zu X ; Qi L ; Cao X Stem Cells Transl Med 2017[Feb]; 6 (2 ): 394-404 PMID28191756 show ga Benign prostatic hyperplasia (BPH) is the overgrowth of prostate tissues with high prevalence in older men. BPH pathogenesis is not completely understood, but it is believed to be a result of de novo overgrowth of prostatic stroma. In this study, we show that aberrant activation of transforming growth factor-? (TGF-?) mobilizes mesenchymal/stromal stem cells (MSCs) in circulating blood, which are recruited for the prostatic stromal hyperplasia. Elevated levels of active TGF-? were observed in both a phenylephrine-induced prostatic hyperplasia mouse model and human BPH tissues. Nestin lineage tracing revealed that 39.6% ± 6.3% of fibroblasts and 73.3% ± 4.2% smooth muscle cells were derived from nestin(+) cells in Nestin-Cre, Rosa26-YFP(flox/+) mice. Nestin(+) MSCs were increased in the prostatic hyperplasia mice. Our parabiosis experiment demonstrate that nestin(+) MSCs were mobilized and recruited to the prostatic stroma of wild-type mice and gave rise to the fibroblasts. Moreover, injection of a TGF-? neutralizing antibody (1D11) inhibits mobilization of MSCs, their recruitment to the prostatic stroma and hyperplasia. Importantly, knockout of T?RII in nestin(+) cell lineage ameliorated stromal hyperplasia. Thus, elevated levels of TGF-?-induced mobilization and recruitment of MSCs to the reactive stroma resulting in overgrowth of prostate tissues in BPH and, thus, inhibition of TGF-? activity could be a potential therapy for BPH. Stem Cells Translational Medicine 2017;6:394-404. |*Cell Movement/drug effects [MESH] |*Cell Proliferation/drug effects [MESH] |Animals [MESH] |Antibodies, Neutralizing/pharmacology [MESH] |Case-Control Studies [MESH] |Cell Lineage [MESH] |Cells, Cultured [MESH] |Disease Models, Animal [MESH] |Fibroblasts/drug effects/*metabolism/pathology [MESH] |Humans [MESH] |Hyperplasia [MESH] |Male [MESH] |Mesenchymal Stem Cells/drug effects/*metabolism/pathology [MESH] |Mice, Inbred C57BL [MESH] |Mice, Transgenic [MESH] |Nestin/genetics/metabolism [MESH] |Parabiosis [MESH] |Phenotype [MESH] |Prostate/drug effects/*metabolism/pathology [MESH] |Prostatic Hyperplasia/genetics/*metabolism/pathology/prevention & control [MESH] |Receptor, Transforming Growth Factor-beta Type II/genetics/metabolism [MESH] |Signal Transduction [MESH]Aberrant Transforming Growth Factor-? Activation Recruits Mesenchymal (epmc).pdf DeepDyve Pubget Overpricing