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10.5966/sctm.2016-0012 http://scihub22266oqcxt.onion/10.5966/sctm.2016-0012 C5442732!5442732 !28170174     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28170174 &cmd=llinks): Failed to open stream: HTTP request failed! 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Transplantation of Donor-Origin Mouse Embryonic Stem Cell-Derived Thymic Epithelial Progenitors Prevents the Development of Chronic Graft-versus-Host Disease in Mice |pdf=|usr=}}{{28170174 }} gab.com Text Transplantation of Donor-Origin Mouse Embryonic Stem Cell-Derived Thymic Epithelial Progenitors Prevents the Development of Chronic Graft-versus-Host Disease in Mice JO: Stem Cells Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=28170174 #FOAvip Allogeneic hematopoietic stem cell transplantation (HSCT) is a potentially curative therapy for many malignant and nonmalignant diseases. However, chronic graft-versus-host disease (cGVHD) remains a significant cause of late morbidity and mortality after allogeneic HSCT. cGVHD often manifests as autoimmune syndrome. Thymic epithelial cells (TECs) play a critical role in supporting negative selection and regulatory T-cell (Treg) generation. Studies have shown that damage in TECs is sufficient to induce cGVHD. We have previously reported that mouse embryonic stem cells (mESCs) can be selectively induced to generate thymic epithelial progenitors (TEPs) in vitro. When transplanted in vivo, mESC-TEPs further develop into TECs that support T-cell development. We show here that transplantation of donor-origin mESC-TEPs into cGVHD recipients induces immune tolerance to both donor and host antigens and prevents the development of cGVHD. This is associated with more TECs and Tregs. Our results suggest that embryonic stem cell-derived TEPs may offer a new tool to control cGVHD. Stem Cells Translational Medicine 2017;6:121-130. Twit Text FOAVip Transplantation of Donor-Origin Mouse Embryonic Stem Cell-Derived Thymic Epithelial Progenitors Prevents the Development of Chronic Graft-versus-Host Disease in Mice ????Stem Cells Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=28170174 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28170174 #FOAvip English Wikipedia <ref>{{Cite pmid|28170174 }}</ref> Transplantation of Donor-Origin Mouse Embryonic Stem Cell-Derived Thymic Epithelial Progenitors Prevents the Development of Chronic Graft-versus-Host Disease in Mice #MMPMID28170174 Hu R ; Liu Y ; Su M ; Song Y ; Rood D ; Lai L Stem Cells Transl Med 2017[Jan]; 6 (1 ): 121-130 PMID28170174 show ga Allogeneic hematopoietic stem cell transplantation (HSCT) is a potentially curative therapy for many malignant and nonmalignant diseases. However, chronic graft-versus-host disease (cGVHD) remains a significant cause of late morbidity and mortality after allogeneic HSCT. cGVHD often manifests as autoimmune syndrome. Thymic epithelial cells (TECs) play a critical role in supporting negative selection and regulatory T-cell (Treg) generation. Studies have shown that damage in TECs is sufficient to induce cGVHD. We have previously reported that mouse embryonic stem cells (mESCs) can be selectively induced to generate thymic epithelial progenitors (TEPs) in vitro. When transplanted in vivo, mESC-TEPs further develop into TECs that support T-cell development. We show here that transplantation of donor-origin mESC-TEPs into cGVHD recipients induces immune tolerance to both donor and host antigens and prevents the development of cGVHD. This is associated with more TECs and Tregs. Our results suggest that embryonic stem cell-derived TEPs may offer a new tool to control cGVHD. Stem Cells Translational Medicine 2017;6:121-130. |*Stem Cell Transplantation [MESH] |Animals [MESH] |Antigens/metabolism [MESH] |Cell Count [MESH] |Cell Differentiation [MESH] |Chronic Disease [MESH] |Epithelial Cells/cytology/*transplantation [MESH] |Graft vs Host Disease/immunology/pathology/*prevention & control [MESH] |Immune Tolerance [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |Mice, Inbred C57BL [MESH] |Mouse Embryonic Stem Cells/cytology/*transplantation [MESH] |T-Lymphocytes, Regulatory/cytology [MESH] |Thymocytes/cytology [MESH]Transplantation of Donor-Origin Mouse Embryonic Stem Cell-Derived Thym(epmc).pdf DeepDyve Pubget Overpricing