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10.1186/s12967-017-1214-8 http://scihub22266oqcxt.onion/10.1186/s12967-017-1214-8 C5442653!5442653!28535799     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28535799&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Transl+Med 2017 ; 15 (ä): ä Nephropedia Template TP {{tp|p=28535799|t=2017. The spleen in liver cirrhosis: revisiting an old enemy with novel targets |pdf=|usr=}}{{28535799}} gab.com Text The spleen in liver cirrhosis: revisiting an old enemy with novel targets JO: J Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=28535799 #FOAvip The spleen is a secondary lymphoid organ which can influence the progression of multiple diseases, notably liver cirrhosis. In chronic liver diseases, splenomegaly and hypersplenism can manifest following the development of portal hypertension. These splenic abnormalities correlate with and have been postulated to facilitate the progression of liver fibrosis to cirrhosis, although precise mechanisms remain poorly understood. In this review, we summarize the literature to highlight the mechanistic contributions of splenomegaly and hypersplenism to the development of liver cirrhosis, focusing on three key aspects: hepatic fibrogenesis, hepatic immune microenvironment dysregulation and liver regeneration. We conclude with a discussion of the possible therapeutic strategies for modulating splenic abnormalities, including the novel potential usage of nanomedicine in non-surgically targetting splenic disorders for the treatment of liver cirrhosis. Twit Text FOAVip The spleen in liver cirrhosis: revisiting an old enemy with novel targets ????J Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=28535799 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28535799 #FOAvip English Wikipedia <ref>{{Cite pmid|28535799}}</ref> The spleen in liver cirrhosis: revisiting an old enemy with novel targets #MMPMID28535799 Li L; Duan M; Chen W; Jiang A; Li X; Yang J; Li Z J Transl Med 2017[]; 15 (ä): ä PMID28535799show ga The spleen is a secondary lymphoid organ which can influence the progression of multiple diseases, notably liver cirrhosis. In chronic liver diseases, splenomegaly and hypersplenism can manifest following the development of portal hypertension. These splenic abnormalities correlate with and have been postulated to facilitate the progression of liver fibrosis to cirrhosis, although precise mechanisms remain poorly understood. In this review, we summarize the literature to highlight the mechanistic contributions of splenomegaly and hypersplenism to the development of liver cirrhosis, focusing on three key aspects: hepatic fibrogenesis, hepatic immune microenvironment dysregulation and liver regeneration. We conclude with a discussion of the possible therapeutic strategies for modulating splenic abnormalities, including the novel potential usage of nanomedicine in non-surgically targetting splenic disorders for the treatment of liver cirrhosis. äThe spleen in liver cirrhosis: revisiting an old enemy with novel targ(epmc).pdf DeepDyve Pubget Overpricing